With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.

Chavas, L., Kato, R., Suzuki, N., von Itzstein, M., Mann, M., Thomson, R., et al. (2010). Complexity in influenza virus targeted drug design: interaction with human sialidases. JOURNAL OF MEDICINAL CHEMISTRY, 53(7), 2998-3002 [10.1021/jm100078r].

Complexity in influenza virus targeted drug design: interaction with human sialidases

FUSI, PAOLA ALESSANDRA;
2010

Abstract

With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.
Articolo in rivista - Articolo scientifico
Molecular Conformation; Models, Molecular; Influenza A Virus, H1N1 Subtype; Enzyme Inhibitors; Orthomyxoviridae; Influenza A Virus, H5N1 Subtype; Neuraminidase; Drug Design; Humans; Crystallography, X-Ray
English
2010
53
7
2998
3002
none
Chavas, L., Kato, R., Suzuki, N., von Itzstein, M., Mann, M., Thomson, R., et al. (2010). Complexity in influenza virus targeted drug design: interaction with human sialidases. JOURNAL OF MEDICINAL CHEMISTRY, 53(7), 2998-3002 [10.1021/jm100078r].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/22164
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