In the last decades, new technologies have been introduced in the daily clinical practice of the radiation oncologist: 3D-Conformal radiotherapy (RT) became almost universally available, thereafter, intensity modulated RT (IMRT) gained large diffusion, due to its potential impact in improving the clinical outcomes, and more recently, helical and volumetric arc IMRT with image-guided RT are becoming more and more diffused and used for prostate cancer patients. The conventional dose-fractionation results to be the best compromise between the efficacy and the safety of the treatment, but combining new techniques, modern RT allows to overcame one of the major limits of the 'older' RT: the impossibility of delivering higher total doses and/or high dose/fraction. The evidences regarding radiobiology, clinical and technological evolution of RT in prostate cancer have been reported and discussed

De Bari, B., Fiorentino, A., Arcangeli, S., Franco, P., D'Angelillo, R., Alongi, F. (2014). From radiobiology to technology: what is changing in radiotherapy for prostate cancer. EXPERT REVIEW OF ANTICANCER THERAPY, 14(5), 553-564 [10.1586/14737140.2014.883282].

From radiobiology to technology: what is changing in radiotherapy for prostate cancer

Arcangeli S;
2014

Abstract

In the last decades, new technologies have been introduced in the daily clinical practice of the radiation oncologist: 3D-Conformal radiotherapy (RT) became almost universally available, thereafter, intensity modulated RT (IMRT) gained large diffusion, due to its potential impact in improving the clinical outcomes, and more recently, helical and volumetric arc IMRT with image-guided RT are becoming more and more diffused and used for prostate cancer patients. The conventional dose-fractionation results to be the best compromise between the efficacy and the safety of the treatment, but combining new techniques, modern RT allows to overcame one of the major limits of the 'older' RT: the impossibility of delivering higher total doses and/or high dose/fraction. The evidences regarding radiobiology, clinical and technological evolution of RT in prostate cancer have been reported and discussed
Articolo in rivista - Review Essay
RADIOBIOLOGY; TECHNOLOGY; PROSTATE CANCER
English
2014
14
5
553
564
reserved
De Bari, B., Fiorentino, A., Arcangeli, S., Franco, P., D'Angelillo, R., Alongi, F. (2014). From radiobiology to technology: what is changing in radiotherapy for prostate cancer. EXPERT REVIEW OF ANTICANCER THERAPY, 14(5), 553-564 [10.1586/14737140.2014.883282].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/221612
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