Rationale Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30–50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung. Objectives We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung. Findings The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin. Conclusions Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB.

Panico, F., Casali, C., Rossi, G., Rizzi, F., Morandi, U., Bettuzzi, S., et al. (2013). Prognostic role of clusterin in resected adenocarcinomas of the lung. LUNG CANCER, 79, 294-299 [10.1016/j.lungcan.2012.11.024].

Prognostic role of clusterin in resected adenocarcinomas of the lung

Luppi Fabrizio.
2013

Abstract

Rationale Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30–50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung. Objectives We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung. Findings The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin. Conclusions Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB.
Articolo in rivista - Articolo scientifico
Biomarkers; Bronchioloalveolar carcinoma; Non-small cell lung carcinoma; Immunohistochemistry; Relapse; Survival
English
2013
79
294
299
none
Panico, F., Casali, C., Rossi, G., Rizzi, F., Morandi, U., Bettuzzi, S., et al. (2013). Prognostic role of clusterin in resected adenocarcinomas of the lung. LUNG CANCER, 79, 294-299 [10.1016/j.lungcan.2012.11.024].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/221410
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