Herpes zoster (HZ) is typically characterized by pain involving the area of vesicular eruption. Several patients, however, complain of unilateral radicular pain without rash (zoster sine herpete [ZSH]). To evaluate whether the severity and duration of pain and the use of analgesics are greater in ZSH patients than in typical HZ with rash, 16 consecutive patients with acute unilateral pain, without vesicular eruption (ZSH), were compared with 16 controls suffering from typical HZ eruption. Only patients with laboratory evidence of varicella-zoster virus (VZV) reactivation were selected. Serum samples were obtained from all patients at their initial visit and 1 and 2 months later. Monthly, the administered therapies and the average pain score (visual analog scale [VAS] score) were recorded. VZV DNA persisted statistically higher in ZSH sera than HZ sera 1 month after onset (P = 0.0007). ZSH patients averaged greater pain than HZ patients, scoring VAS 76.88 and 66.88 (P = 0.0012), respectively. ZSH patients used significantly more opioid therapy than HZ patients (P = 0.0449; OR, 9.00). This is the first study comparing pain in ZSH and HZ patients: greater severity and duration of pain and more opioid use was detected in patients with ZSH.

Drago, F., Herzum, A., Ciccarese, G., Broccolo, F., Rebora, A., & Parodi, A. (2019). Acute pain and postherpetic neuralgia related to Varicella zoster virus reactivation: Comparison between typical herpes zoster and zoster sine herpete. JOURNAL OF MEDICAL VIROLOGY, 91(2), 287-295 [10.1002/jmv.25304].

Acute pain and postherpetic neuralgia related to Varicella zoster virus reactivation: Comparison between typical herpes zoster and zoster sine herpete

Broccolo, F
Membro del Collaboration Group
;
2019

Abstract

Herpes zoster (HZ) is typically characterized by pain involving the area of vesicular eruption. Several patients, however, complain of unilateral radicular pain without rash (zoster sine herpete [ZSH]). To evaluate whether the severity and duration of pain and the use of analgesics are greater in ZSH patients than in typical HZ with rash, 16 consecutive patients with acute unilateral pain, without vesicular eruption (ZSH), were compared with 16 controls suffering from typical HZ eruption. Only patients with laboratory evidence of varicella-zoster virus (VZV) reactivation were selected. Serum samples were obtained from all patients at their initial visit and 1 and 2 months later. Monthly, the administered therapies and the average pain score (visual analog scale [VAS] score) were recorded. VZV DNA persisted statistically higher in ZSH sera than HZ sera 1 month after onset (P = 0.0007). ZSH patients averaged greater pain than HZ patients, scoring VAS 76.88 and 66.88 (P = 0.0012), respectively. ZSH patients used significantly more opioid therapy than HZ patients (P = 0.0449; OR, 9.00). This is the first study comparing pain in ZSH and HZ patients: greater severity and duration of pain and more opioid use was detected in patients with ZSH.
Articolo in rivista - Articolo scientifico
Scientifica
herpesvirus; pain; reactivation; varicella zoster; varicella-zoster virus (VZV)-DNA; zoster sine herpete (ZSH);
VZV
English
Drago, F., Herzum, A., Ciccarese, G., Broccolo, F., Rebora, A., & Parodi, A. (2019). Acute pain and postherpetic neuralgia related to Varicella zoster virus reactivation: Comparison between typical herpes zoster and zoster sine herpete. JOURNAL OF MEDICAL VIROLOGY, 91(2), 287-295 [10.1002/jmv.25304].
Drago, F; Herzum, A; Ciccarese, G; Broccolo, F; Rebora, A; Parodi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/220619
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