To evaluate the usefulness of structural and biochemical imaging techniques for the diagnosis of uveal melanoma, 12 patients with choroidal melanoma were examined. Magnetic resonance imaging was used in 11 of 12 patients, as one had a metal prosthesis. All the subjects underwent single photon planar scintigraphy (SPPS) and single photon emission computed tomography (SPECT) using the 99mTc-labeled F(ab')2 of the anti-melanoma monoclonal antibody 225.28S ([99mTc]MoAb) and positron emission tomography (PET) using [18F]fluorodeoxyglucose ([18F]FDG). Magnetic resonance identified 6 of 11 melanotic lesions (definite melanomas) and 4 of 11 hypomelanotic lesions (probable melanomas), whereas in one case it was inconclusive. [99mTc]MoAb uptake was observed in 5 of 12 lesions using SPPS and 8 of 12 lesions using SPECT. [18F]FDG uptake was observed in 3 of 12 lesions by PET. These results demonstrate that both MR and radioimmunoscintigraphy are sensitive techniques for the diagnosis of choroidal melanomas and suggest that the detection of melanomas by MR, SPPS, and SPECT is largely dependent upon their size. The validity of these conclusions was verified in four subjects in whom the diagnosis was based on MR and/or SPECT findings only and confirmed by histology. The finding that only some of the uveal melanomas of larger size are visualized based on [18F]FDG uptake suggests that melanomas can have either high or low glucose consumption

Lucignani, G., Paganelli, G., Modorati, G., Pieralli, S., Rizzo, G., Magnani, P., et al. (1992). MRI, antibody-guided scintigraphy, and glucose metabolism in uveal melanoma. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 16(1), 77-83.

MRI, antibody-guided scintigraphy, and glucose metabolism in uveal melanoma

LANDONI, CLAUDIO;FAZIO, FERRUCCIO
1992

Abstract

To evaluate the usefulness of structural and biochemical imaging techniques for the diagnosis of uveal melanoma, 12 patients with choroidal melanoma were examined. Magnetic resonance imaging was used in 11 of 12 patients, as one had a metal prosthesis. All the subjects underwent single photon planar scintigraphy (SPPS) and single photon emission computed tomography (SPECT) using the 99mTc-labeled F(ab')2 of the anti-melanoma monoclonal antibody 225.28S ([99mTc]MoAb) and positron emission tomography (PET) using [18F]fluorodeoxyglucose ([18F]FDG). Magnetic resonance identified 6 of 11 melanotic lesions (definite melanomas) and 4 of 11 hypomelanotic lesions (probable melanomas), whereas in one case it was inconclusive. [99mTc]MoAb uptake was observed in 5 of 12 lesions using SPPS and 8 of 12 lesions using SPECT. [18F]FDG uptake was observed in 3 of 12 lesions by PET. These results demonstrate that both MR and radioimmunoscintigraphy are sensitive techniques for the diagnosis of choroidal melanomas and suggest that the detection of melanomas by MR, SPPS, and SPECT is largely dependent upon their size. The validity of these conclusions was verified in four subjects in whom the diagnosis was based on MR and/or SPECT findings only and confirmed by histology. The finding that only some of the uveal melanomas of larger size are visualized based on [18F]FDG uptake suggests that melanomas can have either high or low glucose consumption
Articolo in rivista - Articolo scientifico
Scientifica
Radioimmunodetection; Melanoma; Fluorodeoxyglucose F18; Tomography, Emission-Computed, Single-Photon; Magnetic Resonance Imaging; Ciliary Body; Choroid Neoplasms; Deoxyglucose; Tomography, Emission-Computed; Uveal Neoplasms; Humans
English
Lucignani, G., Paganelli, G., Modorati, G., Pieralli, S., Rizzo, G., Magnani, P., et al. (1992). MRI, antibody-guided scintigraphy, and glucose metabolism in uveal melanoma. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 16(1), 77-83.
Lucignani, G; Paganelli, G; Modorati, G; Pieralli, S; Rizzo, G; Magnani, P; Colombo, F; Zito, F; Landoni, C; Scotti, G; Brancato, R; Fazio, F
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/22060
Citazioni
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 30
Social impact