Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. © 2013 Elsevier Inc.
Swiers, G., Rode, C., Azzoni, E., De Bruijn, M. (2013). A short history of hemogenic endothelium. BLOOD CELLS, MOLECULES, & DISEASES, 51(4), 206-212 [10.1016/j.bcmd.2013.09.005].
A short history of hemogenic endothelium
Azzoni, EMembro del Collaboration Group
;
2013
Abstract
Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. © 2013 Elsevier Inc.
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