Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. © 2013 Elsevier Inc.

Swiers, G., Rode, C., Azzoni, E., De Bruijn, M. (2013). A short history of hemogenic endothelium. BLOOD CELLS, MOLECULES, & DISEASES, 51(4), 206-212 [10.1016/j.bcmd.2013.09.005].

A short history of hemogenic endothelium

Azzoni, E
Membro del Collaboration Group
;
2013

Abstract

Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. © 2013 Elsevier Inc.
Articolo in rivista - Review Essay
Endothelial to hematopoietic transition; Hematopoiesis; Hematopoietic stem cell; Hemogenic endothelium; Microenvironment; Animals; Cell Lineage; Cell Transdifferentiation; Cellular Microenvironment; Endothelium; Hematopoiesis; Hematopoietic Stem Cells; Humans; Transcription Factors; Molecular Medicine; Molecular Biology; Hematology; Cell Biology
English
2013
51
4
206
212
reserved
Swiers, G., Rode, C., Azzoni, E., De Bruijn, M. (2013). A short history of hemogenic endothelium. BLOOD CELLS, MOLECULES, & DISEASES, 51(4), 206-212 [10.1016/j.bcmd.2013.09.005].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/218618
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