The ability of nanoparticles to evade the immune system, cross biological barriers, and localize at the target tissue ultimately determines their therapeutic potential. Leukocytes naturally encompass all of these features and, therefore, provide great inspiration in biomimetic vectors. Herein, we present a hybrid drug delivery system, termed leukolike vectors, composed of a synthetic nanoporous silicon core cloaked with cellular membranes derived from circulating white blood cells. These particles possess the ability to avoid clearance by the mononuclear phagocyte system, interact with endothelial cells through receptor-ligand interaction, and effi ciently deliver a therapeutic payload to infl amed endothelia. Furthermore, in vivo studies revealed an ability to retain the leukocyte membrane's biological function following systemic administration, demonstrating prolonged circulation and improved tumor targeting abilities.

Furman, N., Molinaro, R., Parodi, A., Evangelopoulos, M., Martinez, J., Corbo, C., et al. (2016). Case Study: Application of leukoLike technology to camouflage nanoparticles from the immune recognition. In Handbook of Immunological properties of engineered nanomaterials (pp. 43-68). World Scientific Publishing Co. Pte. Ltd. [10.1142/9677].

Case Study: Application of leukoLike technology to camouflage nanoparticles from the immune recognition

Corbo, C;
2016

Abstract

The ability of nanoparticles to evade the immune system, cross biological barriers, and localize at the target tissue ultimately determines their therapeutic potential. Leukocytes naturally encompass all of these features and, therefore, provide great inspiration in biomimetic vectors. Herein, we present a hybrid drug delivery system, termed leukolike vectors, composed of a synthetic nanoporous silicon core cloaked with cellular membranes derived from circulating white blood cells. These particles possess the ability to avoid clearance by the mononuclear phagocyte system, interact with endothelial cells through receptor-ligand interaction, and effi ciently deliver a therapeutic payload to infl amed endothelia. Furthermore, in vivo studies revealed an ability to retain the leukocyte membrane's biological function following systemic administration, demonstrating prolonged circulation and improved tumor targeting abilities.
Capitolo o saggio
immune recognition, nanoparticles
English
Handbook of Immunological properties of engineered nanomaterials
2016
9789814699167
3
World Scientific Publishing Co. Pte. Ltd.
43
68
Furman, N., Molinaro, R., Parodi, A., Evangelopoulos, M., Martinez, J., Corbo, C., et al. (2016). Case Study: Application of leukoLike technology to camouflage nanoparticles from the immune recognition. In Handbook of Immunological properties of engineered nanomaterials (pp. 43-68). World Scientific Publishing Co. Pte. Ltd. [10.1142/9677].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/217989
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