The sympathetic nervous system participates in the development and progression of the essential hypertensive state, as shown by increased circulating plasma levels of the adrenergic neurotransmitter norepinephrine, elevated norepinephrine spillover rate, and augmented sympathetic nerve traffic discharge detected in the high blood pressure state. In addition, the sympathetic overdrive participates in the development of the metabolic disarray as well as target organ damage frequently detected in this condition. The above mentioned sympathetic abnormalities explain why adrenergic overdrive represents an important therapeutic target in the treatment of hypertension

Mancia, G., Grassi, G. (2013). The central sympathetic nervous system in hypertension. In Handbook of Clinical Neurology, Autonomic Nervous System (pp. 329-335). Elsevier B.V. [10.1016/B978-0-444-53491-0.00026-2].

The central sympathetic nervous system in hypertension

Mancia, G;Grassi, G
2013

Abstract

The sympathetic nervous system participates in the development and progression of the essential hypertensive state, as shown by increased circulating plasma levels of the adrenergic neurotransmitter norepinephrine, elevated norepinephrine spillover rate, and augmented sympathetic nerve traffic discharge detected in the high blood pressure state. In addition, the sympathetic overdrive participates in the development of the metabolic disarray as well as target organ damage frequently detected in this condition. The above mentioned sympathetic abnormalities explain why adrenergic overdrive represents an important therapeutic target in the treatment of hypertension
Capitolo o saggio
Autonomic function, Baroreflex, Heart rate, Hypertension, Norepinephrine, Sympathetic nervous system
English
Handbook of Clinical Neurology, Autonomic Nervous System
2013
117
Elsevier B.V.
329
335
Mancia, G., Grassi, G. (2013). The central sympathetic nervous system in hypertension. In Handbook of Clinical Neurology, Autonomic Nervous System (pp. 329-335). Elsevier B.V. [10.1016/B978-0-444-53491-0.00026-2].
none
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/217711
Citazioni
  • Scopus 10
  • ???jsp.display-item.citation.isi??? ND
Social impact