Tumor cell migration and invasion are critical steps in the complex process of metastasis formation. It has been demonstrated that interferons (IFNs) inhibit the motility of human fibroblasts. In the present investigation we tested the effect of human leukocyte IFN and murine fibroblast IFN on the chemotactic migration of transformed and tumor-derived cells towards fibroblast conditioned medium. We were able to show that IFNs preferentially inhibit the chemotaxis of transformed and tumor-derived cell lines when compared to control fibroblasts. Inhibition was dose-dependent and most tumor cell strains were sensitive to concentrations of IFNs 10- to 100-fold lower than fibroblast cultures. Furthermore, leukocyte interferon was able to inhibit the invasion of transformed 3T3 fibroblasts through a gel of reconstituted basement membrane (Matrigel). These effects could be related to the antineoplastic activity of interferon

Melchiori, A., Allavena, G., Bohm, J., Remy, W., Schmidt, J., Parodi, S., et al. (1987). Interferons inhibit chemotaxis of transformed cells and their invasion of a reconstituted basement membrane. ANTICANCER RESEARCH, 7(3B), 475-479.

Interferons inhibit chemotaxis of transformed cells and their invasion of a reconstituted basement membrane

ALBINI A
1987

Abstract

Tumor cell migration and invasion are critical steps in the complex process of metastasis formation. It has been demonstrated that interferons (IFNs) inhibit the motility of human fibroblasts. In the present investigation we tested the effect of human leukocyte IFN and murine fibroblast IFN on the chemotactic migration of transformed and tumor-derived cells towards fibroblast conditioned medium. We were able to show that IFNs preferentially inhibit the chemotaxis of transformed and tumor-derived cell lines when compared to control fibroblasts. Inhibition was dose-dependent and most tumor cell strains were sensitive to concentrations of IFNs 10- to 100-fold lower than fibroblast cultures. Furthermore, leukocyte interferon was able to inhibit the invasion of transformed 3T3 fibroblasts through a gel of reconstituted basement membrane (Matrigel). These effects could be related to the antineoplastic activity of interferon
Articolo in rivista - Articolo scientifico
Basement Membrane/pathology Cell Line Cell Transformation, Neoplastic Chemotaxis/*drug effects Dose-Response Relationship, Drug Fibronectins/physiology Interferons/*pharmacology *Neoplasm Invasiveness Neoplasms/*pathology
English
1987
7
3B
475
479
none
Melchiori, A., Allavena, G., Bohm, J., Remy, W., Schmidt, J., Parodi, S., et al. (1987). Interferons inhibit chemotaxis of transformed cells and their invasion of a reconstituted basement membrane. ANTICANCER RESEARCH, 7(3B), 475-479.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/215379
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