Fragments derived from human plasma fibronectin by enzymatic degradation were tested in the Boyden chamber for chemotactic activity towards various fibroblast strains. The results provide clear evidence that the chemotactic activity is restricted to a defined region of the fibronectin molecule which is the same for various fibroblast strains. The active domain is localized between the collagen binding site and the major heparin binding site, about 170 kDa apart from the N-terminal and about 70 kDa from the C-terminal ends of the two subunit peptide chains.

Albini, A., Richter, H., Pontz, B. (1983). Localization of the chemotactic domain in fibronectin. FEBS LETTERS, 156(2), 222-226 [10.1016/0014-5793(83)80500-6].

Localization of the chemotactic domain in fibronectin

Albini A;
1983

Abstract

Fragments derived from human plasma fibronectin by enzymatic degradation were tested in the Boyden chamber for chemotactic activity towards various fibroblast strains. The results provide clear evidence that the chemotactic activity is restricted to a defined region of the fibronectin molecule which is the same for various fibroblast strains. The active domain is localized between the collagen binding site and the major heparin binding site, about 170 kDa apart from the N-terminal and about 70 kDa from the C-terminal ends of the two subunit peptide chains.
Articolo in rivista - Articolo scientifico
Binding Sites, Cells, Cultured, *Chemotactic Factors, Fibroblasts/metabolism/physiology, Fibronectins/*isolation & purification, Fibrosarcoma/physiopathology, Human, Hydrolysis, Peptide Fragments/isolation & purification Rhabdomyosarcoma/
English
1983
156
2
222
226
none
Albini, A., Richter, H., Pontz, B. (1983). Localization of the chemotactic domain in fibronectin. FEBS LETTERS, 156(2), 222-226 [10.1016/0014-5793(83)80500-6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/215297
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