Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends
Gobbini, E., Vertemara, J., & Longhese, M. (2018). Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity. MOLECULAR & CELLULAR ONCOLOGY, 5(5) [10.1080/23723556.2018.1511208].
Citazione: | Gobbini, E., Vertemara, J., & Longhese, M. (2018). Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity. MOLECULAR & CELLULAR ONCOLOGY, 5(5) [10.1080/23723556.2018.1511208]. | |
Tipo: | Articolo in rivista - Review Essay | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity | |
Autori: | Gobbini, E; Vertemara, J; Longhese, M | |
Autori: | GOBBINI, ELISA (Primo) VERTEMARA, JACOPO (Secondo) LONGHESE, MARIA PIA (Ultimo) (Corresponding) | |
Data di pubblicazione: | 2018 | |
Lingua: | English | |
Rivista: | MOLECULAR & CELLULAR ONCOLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/23723556.2018.1511208 | |
Appare nelle tipologie: | 01 - Articolo su rivista |
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