Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends
Gobbini, E., Vertemara, J., Longhese, M. (2018). Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity. MOLECULAR & CELLULAR ONCOLOGY, 5(5) [10.1080/23723556.2018.1511208].
Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity
Gobbini, ElisaPrimo
;Vertemara, JacopoSecondo
;Longhese, Maria Pia
Ultimo
2018
Abstract
Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends
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