Objective: The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND). Methods: We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging. Results: One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively. Pelvic LD was performed on 115 patients (67.2%) and aortic dissection was performed in 54/105 of the women in the S-LND group (51%). The 5-year comparison did not show a significant difference in the strategy adopted for nodal staging, regarding disease-free survival (DFS) [HR: 0.82; 95% CI 0.53–1.28; p = 0.390]. Conclusions: In this study focusing on women with EC in the HR groups, we did not find a difference in the 5-year DFS when comparing the SLN-A strategy with S-LND. The SLN strategy did not seem to compromise the prognosis of patients with a higher risk of recurrence.

Buda, A., Gasparri, M., Puppo, A., Mereu, L., De Ponti, E., Di Martino, G., et al. (2018). Lymph node evaluation in high-risk early stage endometrial cancer: A multi-institutional retrospective analysis comparing the sentinel lymph node (SLN) algorithm and SLN with selective lymphadenectomy. GYNECOLOGIC ONCOLOGY, 150(2), 261-266 [10.1016/j.ygyno.2018.06.003].

Lymph node evaluation in high-risk early stage endometrial cancer: A multi-institutional retrospective analysis comparing the sentinel lymph node (SLN) algorithm and SLN with selective lymphadenectomy

Buda, A
;
De Ponti, E;Di Martino, G;Landoni, F;
2018

Abstract

Objective: The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND). Methods: We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging. Results: One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively. Pelvic LD was performed on 115 patients (67.2%) and aortic dissection was performed in 54/105 of the women in the S-LND group (51%). The 5-year comparison did not show a significant difference in the strategy adopted for nodal staging, regarding disease-free survival (DFS) [HR: 0.82; 95% CI 0.53–1.28; p = 0.390]. Conclusions: In this study focusing on women with EC in the HR groups, we did not find a difference in the 5-year DFS when comparing the SLN-A strategy with S-LND. The SLN strategy did not seem to compromise the prognosis of patients with a higher risk of recurrence.
Articolo in rivista - Articolo scientifico
Scientifica
High-risk endometrial cancer; Nodal staging; Selective lymphadenectomy; Sentinel node mapping; Adult; Aged; Aged, 80 and over; Algorithms; Endometrial Neoplasms; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Retrospective Studies; Sentinel Lymph Node; Sentinel Lymph Node Biopsy; Oncology; Obstetrics and Gynecology
English
Buda, A., Gasparri, M., Puppo, A., Mereu, L., De Ponti, E., Di Martino, G., et al. (2018). Lymph node evaluation in high-risk early stage endometrial cancer: A multi-institutional retrospective analysis comparing the sentinel lymph node (SLN) algorithm and SLN with selective lymphadenectomy. GYNECOLOGIC ONCOLOGY, 150(2), 261-266 [10.1016/j.ygyno.2018.06.003].
Buda, A; Gasparri, M; Puppo, A; Mereu, L; De Ponti, E; Di Martino, G; Novelli, A; Tateo, S; Muller, M; Landoni, F; Papadia, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/212850
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