IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy-Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed
Cundari, S., Cavaletti, G. (2009). Thalidomide chemotherapy-induced peripheral neuropathy: Actual status and new perspectives with thalidomide analogues derivatives. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 9(7), 760-768 [10.2174/138955709788452595].
Thalidomide chemotherapy-induced peripheral neuropathy: Actual status and new perspectives with thalidomide analogues derivatives
CAVALETTI, GUIDO ANGELO
2009
Abstract
IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy-Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed
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