The induction and maintenance of T-cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of central and peripheral mechanisms act in parallel to inactivated, eliminated or control autoreactive T cells. Both centrally and peripherally, a key requirement for self-tolerance is the presentation of self-antigens in a correct context. There is now evidence to suggest that dendritic cells (DCs) play a fundamental role in the development of central and peripheral tolerance. In this review, we summarize recent progress toward the definition of the multiple roles of DCs in these processes. We will also discuss the association between defects in the DC compartment and the development of autoimmune responses, with particular reference to DC deregulation in the context of type I diabetes. © 2011 Informa UK, Ltd.

Granucci, F., Zanoni, I. (2011). The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance. AUTOIMMUNITY, 44(1), 23-32 [10.3109/08916931003782148].

The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance.

GRANUCCI, FRANCESCA;ZANONI, IVAN
2011

Abstract

The induction and maintenance of T-cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of central and peripheral mechanisms act in parallel to inactivated, eliminated or control autoreactive T cells. Both centrally and peripherally, a key requirement for self-tolerance is the presentation of self-antigens in a correct context. There is now evidence to suggest that dendritic cells (DCs) play a fundamental role in the development of central and peripheral tolerance. In this review, we summarize recent progress toward the definition of the multiple roles of DCs in these processes. We will also discuss the association between defects in the DC compartment and the development of autoimmune responses, with particular reference to DC deregulation in the context of type I diabetes. © 2011 Informa UK, Ltd.
Articolo in rivista - Articolo scientifico
Dendritic cells; autoimmunity
English
2011
44
1
23
32
none
Granucci, F., Zanoni, I. (2011). The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance. AUTOIMMUNITY, 44(1), 23-32 [10.3109/08916931003782148].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/20891
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