Epigenetic changes play a role and cooperate with genetic alterations in the pathogenesis of myelodysplastic syndromes (MDS). We conducted a phase II multicenter study on the combination of the DNA-methyltransferase inhibitor 5-azacytidine (5-AZA) and the histone deacetylase inhibitor valproic acid (VPA) in patients with higher risk MDS.

Voso, M., Santini, V., Finelli, C., Musto, P., Pogliani, E., Angelucci, E., et al. (2009). Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. CLINICAL CANCER RESEARCH, 15(15), 5002-5007 [10.1158/1078-0432.CCR-09-0494].

Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes

POGLIANI, ENRICO MARIA;
2009

Abstract

Epigenetic changes play a role and cooperate with genetic alterations in the pathogenesis of myelodysplastic syndromes (MDS). We conducted a phase II multicenter study on the combination of the DNA-methyltransferase inhibitor 5-azacytidine (5-AZA) and the histone deacetylase inhibitor valproic acid (VPA) in patients with higher risk MDS.
Articolo in rivista - Articolo scientifico
Prognosis; Aged, 80 and over; Male; Azacitidine; Middle Aged; Histone Deacetylase Inhibitors; Female; Polymorphism, Single Nucleotide; Drug Therapy, Combination; Valproic Acid; Epigenesis, Genetic; Humans; Aryl Hydrocarbon Hydroxylases; Enzyme Inhibitors; DNA Methylation; Methyltransferases; Aged; Myelodysplastic Syndromes
English
2009
15
15
5002
5007
none
Voso, M., Santini, V., Finelli, C., Musto, P., Pogliani, E., Angelucci, E., et al. (2009). Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. CLINICAL CANCER RESEARCH, 15(15), 5002-5007 [10.1158/1078-0432.CCR-09-0494].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/20848
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