Small-artery remodeling is an early feature of target organ damage in hypertension and retains a negative prognostic value. The aim of the study is to establish age- and sex-specific reference values for media/lumen in small arteries obtained in humans by biopsy. Data from 91 healthy individuals and 200 individuals with cardiovascular risk factors in primary prevention from 4 Italian centers were pooled. Sex-specific equations for media/lumen in the healthy subpopulation, with age as dependent variable, were calculated. These equations were used to calculate predicted media/lumen values in individuals with risk factors and Z scores. The association between classical risk factors and Z scores was then explored by multiple regression analysis. A second-degree polynomial equation model was chosen to obtain sex-specific equations for media/ lumen, with age as dependent variable. In the population with risk factors (111 men, age 50.5±14.0 years, hypertension 80.5%), media/lumen Z scores were independently associated with body mass index (standardized β=0.293, P=0.0001), total cholesterol (β=0.191, P=0.031), current smoking (β=0.238, P=0.0005), fasting blood glucose (β=0.204, P=0.003), systolic blood pressure (β=0.233, P=0.023), and female sex (β=0.799, P=0.038). A significant interaction between female sex and total cholesterol was found (β=-0.979, P=0.014). Results were substantially similar in the hypertensive subgroup. A method to calculate individual values of remodeling and growth index based on reference values was also presented. Age- and sex-specific percentiles of media/lumen in a healthy population were estimated. In a predominantly hypertensive population, media/lumen Z scores were associated with major cardiovascular risk factors, including body mass index, cholesterol, smoking, glucose, and systolic blood pressure. Significant sex differences were observed.
Bruno, R., Grassi, G., Seravalle, G., Savoia, C., Rizzoni, D., & Virdis, A. (2018). Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors. HYPERTENSION, 71(6), 1193-1200 [10.1161/HYPERTENSIONAHA.117.10634].
|Citazione:||Bruno, R., Grassi, G., Seravalle, G., Savoia, C., Rizzoni, D., & Virdis, A. (2018). Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors. HYPERTENSION, 71(6), 1193-1200 [10.1161/HYPERTENSIONAHA.117.10634].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors|
|Autori:||Bruno, R; Grassi, G; Seravalle, G; Savoia, C; Rizzoni, D; Virdis, A|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10634|
|Appare nelle tipologie:||01 - Articolo su rivista|