DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

Ordanini, S., Varga, N., Porkolab, V., Thépaut, M., Belvisi, L., Bertaglia, A., et al. (2015). Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: Ligand presentation using molecular rods. CHEMICAL COMMUNICATIONS, 51(18), 3816-3819 [10.1039/c4cc09709b].

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: Ligand presentation using molecular rods

Palmioli, Alessandro;
2015

Abstract

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
Articolo in rivista - Articolo scientifico
CD4-Positive T-Lymphocytes; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Dendrimers; HIV Infections; HIV-1; Humans; Lectins, C-Type; Ligands; Mannose; Receptors, Cell Surface; Serum Albumin; Catalysis; Electronic, Optical and Magnetic Materials; Ceramics and Composites; Chemistry (all); Surfaces, Coatings and Films; 2506; Materials Chemistry2506 Metals and Alloys
English
2015
51
18
3816
3819
none
Ordanini, S., Varga, N., Porkolab, V., Thépaut, M., Belvisi, L., Bertaglia, A., et al. (2015). Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: Ligand presentation using molecular rods. CHEMICAL COMMUNICATIONS, 51(18), 3816-3819 [10.1039/c4cc09709b].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/206091
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