Clinical proton and ions beams for cancer treatment provide maximum energy deposition (Bragg Peak, BP) at the end of their range and practically no dose behind. This enables a more efficient therapeutic option comparing with classical photon-based radiotherapy where maximum energy deposition occurs at the body/tissues interface. Obviously, optimum/minimum-error BP detection and calibration is thus a key aspect of this treatment. This work investigates a promising detection technique, based on the so called (proton) iono-acoustic effect. The BP energy deposition causes a small (mK) heating of the surrounding region that in turn induces a pressure variation. This propagates an ultrasound signal (MHz range) whose time-of-flight measurement aims to detect the BP position with very high accuracy (<1mm). This paper presents the simulation results of complete mixed-signals and mixed-energies model that starting from proton beam energy calculates the induced pressure variation in water, emulates the propagation of sound waves in the medium and finally provides a voltage signal (including noise) whose time evolution determines BP position.

Riva, M., Vallicelli, E., Baschirotto, A., De Matteis, M. (2018). Acoustic analog front-end for Bragg-Peak detection in hadron therapy. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp.1-4). Institute of Electrical and Electronics Engineers Inc. [10.1109/BIOCAS.2017.8325223].

Acoustic analog front-end for Bragg-Peak detection in hadron therapy

Vallicelli, E;Baschirotto, A;De Matteis, M
2018

Abstract

Clinical proton and ions beams for cancer treatment provide maximum energy deposition (Bragg Peak, BP) at the end of their range and practically no dose behind. This enables a more efficient therapeutic option comparing with classical photon-based radiotherapy where maximum energy deposition occurs at the body/tissues interface. Obviously, optimum/minimum-error BP detection and calibration is thus a key aspect of this treatment. This work investigates a promising detection technique, based on the so called (proton) iono-acoustic effect. The BP energy deposition causes a small (mK) heating of the surrounding region that in turn induces a pressure variation. This propagates an ultrasound signal (MHz range) whose time-of-flight measurement aims to detect the BP position with very high accuracy (<1mm). This paper presents the simulation results of complete mixed-signals and mixed-energies model that starting from proton beam energy calculates the induced pressure variation in water, emulates the propagation of sound waves in the medium and finally provides a voltage signal (including noise) whose time evolution determines BP position.
No
poster + paper
Scientifica
acoustics; analog amplifiers; hadron therapy; iono-acoustic; proton;
acoustics; analog amplifiers; hadron therapy; iono-acoustic; proton; Biomedical Engineering; Electrical and Electronic Engineering; Instrumentation
English
2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
9781509058037
Riva, M., Vallicelli, E., Baschirotto, A., De Matteis, M. (2018). Acoustic analog front-end for Bragg-Peak detection in hadron therapy. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp.1-4). Institute of Electrical and Electronics Engineers Inc. [10.1109/BIOCAS.2017.8325223].
Riva, M; Vallicelli, E; Baschirotto, A; De Matteis, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/205513
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