Clinical ions beams for cancer treatment provide maximum energy deposition (Bragg peak (BP)) at the end of their range and practically no dose behind. This enables a more efficient therapeutic option comparing with classical photon-based radiotherapy where maximum energy is deposited at the body interface. Obviously, minimum-error BP detection is, thus, a key aspect of this treatment. This paper investigates a promising detection technique, based on the so-called ionoacoustic effect. The BP energy deposition causes a small (millikelvin) heating of the surrounding volume that in turn induces a pressure variation. This generates a sound signal that can be detected by an acoustic sensor placed at a certain distance from the BP point. Thus, the sound time-of-flight measure aims, with sound speed, to detect the BP position with very high accuracy (<1 mm). This paper presents the results of a complete cross-domain model that starting from proton beam energy provides the induced pressure variation in water, emulates the propagation of sound waves in the medium, and finally, returns a voltage signal whose time evolution determines BP position with an average deviation from effective position of 1% accuracy.

Riva, M., Vallicelli, E., Baschirotto, A., De Matteis, M. (2018). Acoustic Analog Front End for Proton Range Detection in Hadron Therapy. IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, 12(4), 954-962 [10.1109/TBCAS.2018.2828703].

Acoustic Analog Front End for Proton Range Detection in Hadron Therapy

Vallicelli, Elia Arturo;Baschirotto, Andrea;De Matteis, Marcello
2018

Abstract

Clinical ions beams for cancer treatment provide maximum energy deposition (Bragg peak (BP)) at the end of their range and practically no dose behind. This enables a more efficient therapeutic option comparing with classical photon-based radiotherapy where maximum energy is deposited at the body interface. Obviously, minimum-error BP detection is, thus, a key aspect of this treatment. This paper investigates a promising detection technique, based on the so-called ionoacoustic effect. The BP energy deposition causes a small (millikelvin) heating of the surrounding volume that in turn induces a pressure variation. This generates a sound signal that can be detected by an acoustic sensor placed at a certain distance from the BP point. Thus, the sound time-of-flight measure aims, with sound speed, to detect the BP position with very high accuracy (<1 mm). This paper presents the results of a complete cross-domain model that starting from proton beam energy provides the induced pressure variation in water, emulates the propagation of sound waves in the medium, and finally, returns a voltage signal whose time evolution determines BP position with an average deviation from effective position of 1% accuracy.
Articolo in rivista - Articolo scientifico
Acoustic waves; analog circuits; nuclear imaging; particle accelerator; particle beam measurements;
Acoustic waves; analog circuits; nuclear imaging; particle accelerator; particle beam measurements; Biomedical Engineering; Electrical and Electronic Engineering
English
954
962
9
Riva, M., Vallicelli, E., Baschirotto, A., De Matteis, M. (2018). Acoustic Analog Front End for Proton Range Detection in Hadron Therapy. IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, 12(4), 954-962 [10.1109/TBCAS.2018.2828703].
Riva, M; Vallicelli, E; Baschirotto, A; De Matteis, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/205509
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