The role of donor and recipient factors in initial renal graft non-function

Delayed renal graft function appears to be a complex multifactorial disease that has been related to the premortem condition of the donor total ischemia time (cold or warm), methods of preservation, and surgical harvesting procedure. Perioperative recipient management, recipient variables, and immunologically mediated early injuries have also been implicated. An increased interest in the detection of the possible causes of initial graft nonfunction (IGNF) was recently related to the usual practice of multiorgan procurement. Therefore, we retrospectively investigated the incidence of IGNF in our Department, analyzing the records of 90 consecutive renal donors and recipients with particular attention to the fate of the two harvested kidneys (twin kidney), and comparing the results from multiple organ donors (MOD) with those achieved from single organ donors (SOD)