Background and purpose: Cognitively stimulating life experiences and activities are deemed to moderate the clinical impact of brain damage progressively building a neural and cognitive reserve (CR). CR has been studied extensively in various neurodegenerative disorders, but not in corticobasal degeneration (CBD). Methods: Using Statistical Parametric Mapping 8, years of education, as a determinant of CR, was correlated with tracer uptake on positron emission tomography with 18 F-fluorodeoxyglucose, as a marker of neurodegeneration, in 35 patients with various phenotypes of CBD, including a cognitive–motor composite score or symptoms duration as covariates for controlling disease stage. Results: A cluster of relative hypometabolism was found associated with higher education in the left inferior regions of pre- and post-rolandic gyri and insula, which represent typical loci of neurodegeneration in CBD regardless of clinical presentation. Conclusions: The present findings extend to CBD the evidence gathered in other neurodegenerative disorders that a higher CR has a protective effect against the clinical manifestations of brain degeneration.
Isella, V., Grisanti, S., Ferri, F., Morzenti, S., Crivellaro, C., Musarra, M., et al. (2018). Cognitive reserve maps the core loci of neurodegeneration in corticobasal degeneration. EUROPEAN JOURNAL OF NEUROLOGY, 25(11), 1333-1340 [10.1111/ene.13729].
|Citazione:||Isella, V., Grisanti, S., Ferri, F., Morzenti, S., Crivellaro, C., Musarra, M., et al. (2018). Cognitive reserve maps the core loci of neurodegeneration in corticobasal degeneration. EUROPEAN JOURNAL OF NEUROLOGY, 25(11), 1333-1340 [10.1111/ene.13729].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Cognitive reserve maps the core loci of neurodegeneration in corticobasal degeneration|
|Autori:||Isella, V; Grisanti, S; Ferri, F; Morzenti, S; Crivellaro, C; Musarra, M; Ferrarese, C|
ISELLA, VALERIA (Corresponding)
MORZENTI, SABRINA (Corresponding)
CRIVELLARO, CINZIA (Corresponding)
FERRARESE, CARLO (Corresponding)
|Data di pubblicazione:||2018|
|Rivista:||EUROPEAN JOURNAL OF NEUROLOGY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/ene.13729|
|Appare nelle tipologie:||01 - Articolo su rivista|