Piodermal gangrenosum (PG) is an uncommon ulcerative cutaneous dermatosis associated with a variety of systemic diseases, including inflammatory bowel disease (IBD), arthritis, leukaemia, hepatitis, and primary billiary cirrhosis. Other cutaneous ulceration resembling PG had been described in literature. There has been neither laboratory finding nor histological feature diagnostic of PG, and diagnosis of PG is mainly made based on the exclusion criteria. We present here a patient, with ulcerative colitis (UC) who was referred to the emergency section with a large and rapidly evolving cutaneous ulceration. Laboratory and microbiological investigation associated with histological findings of the ulcer specimen allowed us to exclude autoimmune and systemic diseases as well as immuno-proliferative disorders. An atypical presentation of PG with UC was diagnosed. Pulse boluses of i.v. methyl-prednisolone were started, and after tapering steroids, complete resolution of the skin lesion was achieved in 3 wk. The unusual rapid healing of the skin ulceration with steroid mono-therapy and the atypical cutaneous presentation in this patient as well as the risk of misdiagnosis of PG in the clinical practice were discussed. © 2008 The WJG Press. All rights reserved

Aseni, P., Di Sandro, S., Mihaylov, P., Lamperti, L., De Carlis, L. (2008). Atypical presentation of pioderma gangrenosum complicating ulcerative colitis: Rapid disappearance with methylpredinsolone. WORLD JOURNAL OF GASTROENTEROLOGY, 14(35), 5471-5473 [10.3748/wjg.14.5471].

Atypical presentation of pioderma gangrenosum complicating ulcerative colitis: Rapid disappearance with methylpredinsolone

De Carlis, Luciano Gregorio
2008

Abstract

Piodermal gangrenosum (PG) is an uncommon ulcerative cutaneous dermatosis associated with a variety of systemic diseases, including inflammatory bowel disease (IBD), arthritis, leukaemia, hepatitis, and primary billiary cirrhosis. Other cutaneous ulceration resembling PG had been described in literature. There has been neither laboratory finding nor histological feature diagnostic of PG, and diagnosis of PG is mainly made based on the exclusion criteria. We present here a patient, with ulcerative colitis (UC) who was referred to the emergency section with a large and rapidly evolving cutaneous ulceration. Laboratory and microbiological investigation associated with histological findings of the ulcer specimen allowed us to exclude autoimmune and systemic diseases as well as immuno-proliferative disorders. An atypical presentation of PG with UC was diagnosed. Pulse boluses of i.v. methyl-prednisolone were started, and after tapering steroids, complete resolution of the skin lesion was achieved in 3 wk. The unusual rapid healing of the skin ulceration with steroid mono-therapy and the atypical cutaneous presentation in this patient as well as the risk of misdiagnosis of PG in the clinical practice were discussed. © 2008 The WJG Press. All rights reserved
Articolo in rivista - Articolo scientifico
Cutaneous lesion; Immunosuppression; Pioderma gangrenosum; Steroids; Ulcerative colitis; Gastroenterology
English
2008
14
35
5471
5473
none
Aseni, P., Di Sandro, S., Mihaylov, P., Lamperti, L., De Carlis, L. (2008). Atypical presentation of pioderma gangrenosum complicating ulcerative colitis: Rapid disappearance with methylpredinsolone. WORLD JOURNAL OF GASTROENTEROLOGY, 14(35), 5471-5473 [10.3748/wjg.14.5471].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/203862
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