Introduction: Repeat hepatectomy (RH) is considered a valuable option for management of recurrent colorectal liver metastases (R-CLM). Here, the outcome of RH for R-CLM was compared to that of patients who underwent single hepatectomy (SH) after subdividing the later according to re-recurrence status. Methods: Between 2001 and 2013, patients who received hepatectomy for CLM and R-CLM were included in study. Patients with non-resectable R-CLM were excluded. Results: One hundred sixteen patients were included: 86 patients in SH group and 30 patients in RH group. Repeat hepatectomy group had more synchronous CLM (76.7 versus 50 %, p = 0.011). From the 86 patients who underwent SH, 69 patients did not have R-CLM. Survival analysis was done from the time of first hepatectomy for the no R-CLM group and the time of RH for the RH group. The 3- and 5-year survival rates for the no R-CLM group were 66.4 and 48.8%, respectively, and for the RH group were 56 and 44.8% respectively (p = 0.841). Multivariate analysis showed that larger size of R-CLM is an independent risk factor for survival after RH. Conclusion: Repeat hepatectomy for R-CLM shows a comparable OS to non-recurrent CLM after single hepatectomy, despite the RH group had higher incidence of synchronous CLM.

Ali, M., Di Sandro, S., Lauterio, A., Concone, G., Mangoni, I., Ferla, F., et al. (2015). Repeat Hepatectomy for Recurrent Colorectal Liver Metastases: Is it Worth the Challenge?. JOURNAL OF GASTROINTESTINAL SURGERY, 19(12), 2192-2198 [10.1007/s11605-015-2939-4].

Repeat Hepatectomy for Recurrent Colorectal Liver Metastases: Is it Worth the Challenge?

Lauterio, Andrea;De Carlis, Luciano
2015

Abstract

Introduction: Repeat hepatectomy (RH) is considered a valuable option for management of recurrent colorectal liver metastases (R-CLM). Here, the outcome of RH for R-CLM was compared to that of patients who underwent single hepatectomy (SH) after subdividing the later according to re-recurrence status. Methods: Between 2001 and 2013, patients who received hepatectomy for CLM and R-CLM were included in study. Patients with non-resectable R-CLM were excluded. Results: One hundred sixteen patients were included: 86 patients in SH group and 30 patients in RH group. Repeat hepatectomy group had more synchronous CLM (76.7 versus 50 %, p = 0.011). From the 86 patients who underwent SH, 69 patients did not have R-CLM. Survival analysis was done from the time of first hepatectomy for the no R-CLM group and the time of RH for the RH group. The 3- and 5-year survival rates for the no R-CLM group were 66.4 and 48.8%, respectively, and for the RH group were 56 and 44.8% respectively (p = 0.841). Multivariate analysis showed that larger size of R-CLM is an independent risk factor for survival after RH. Conclusion: Repeat hepatectomy for R-CLM shows a comparable OS to non-recurrent CLM after single hepatectomy, despite the RH group had higher incidence of synchronous CLM.
Articolo in rivista - Articolo scientifico
Colorectal metastases; Liver resection; Liver tumor; Aged; Colorectal Neoplasms; Female; Humans; Incidence; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Reoperation; Survival Analysis; Survival Rate; Hepatectomy; Surgery; Gastroenterology
English
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Ali, M., Di Sandro, S., Lauterio, A., Concone, G., Mangoni, I., Ferla, F., et al. (2015). Repeat Hepatectomy for Recurrent Colorectal Liver Metastases: Is it Worth the Challenge?. JOURNAL OF GASTROINTESTINAL SURGERY, 19(12), 2192-2198 [10.1007/s11605-015-2939-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/203801
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