Starting from EP 51389, a potent growth hormone secretagogue (GHS), a new series of GHS has been designed, synthesized and tested. This series was built on a gem-diamino moiety and a structure activity relationship study was performed including N-methylation of the amide bonds. Some analogues exhibited more powerful activity than Hexarelin, they were active per os on dog and have been selected as candidates for further development.

Guerlavais, V., Boeglin, D., Fehrentz, J., Deghenghi, R., Locatelli, V., Martinez, J. (2001). New growth hormone secretagogues. LETTERS IN PEPTIDE SCIENCE, 8(3-5), 187-193 [10.1023/A:1016293500452].

New growth hormone secretagogues

LOCATELLI, VITTORIO;
2001

Abstract

Starting from EP 51389, a potent growth hormone secretagogue (GHS), a new series of GHS has been designed, synthesized and tested. This series was built on a gem-diamino moiety and a structure activity relationship study was performed including N-methylation of the amide bonds. Some analogues exhibited more powerful activity than Hexarelin, they were active per os on dog and have been selected as candidates for further development.
Articolo in rivista - Articolo scientifico
gem-diamino; growth hormone; GHS; hexarelin; secretagogue
English
2001
8
3-5
187
193
none
Guerlavais, V., Boeglin, D., Fehrentz, J., Deghenghi, R., Locatelli, V., Martinez, J. (2001). New growth hormone secretagogues. LETTERS IN PEPTIDE SCIENCE, 8(3-5), 187-193 [10.1023/A:1016293500452].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/203624
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