Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
Mazzanti, B., Biagioli, T., Aldinucci, A., Cavaletti, G.A., Cavalletti, E., Oggioni, N., et al. (2005). Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 168(1-2), 111-117 [10.1016/j.jneuroim.2005.07.010].
Citazione: | Mazzanti, B., Biagioli, T., Aldinucci, A., Cavaletti, G.A., Cavalletti, E., Oggioni, N., et al. (2005). Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 168(1-2), 111-117 [10.1016/j.jneuroim.2005.07.010]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Titolo: | Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis | |
Autori: | Mazzanti, B; Biagioli, T; Aldinucci, A; Cavaletti, GA; Cavalletti, E; Oggioni, N; Frigo, M; Rota, S; Tagliabue, E; Ballerini, C; Massacesi, L; Riccio, P; Lolli, F | |
Autori: | ||
Data di pubblicazione: | nov-2005 | |
Lingua: | English | |
Rivista: | JOURNAL OF NEUROIMMUNOLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jneuroim.2005.07.010 | |
Appare nelle tipologie: | 01 - Articolo su rivista |