Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
Mazzanti, B., Biagioli, T., Aldinucci, A., Cavaletti, G., Cavalletti, E., Oggioni, N., et al. (2005). Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 168(1-2), 111-117 [10.1016/j.jneuroim.2005.07.010].
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis
CAVALETTI, GUIDO ANGELO;OGGIONI, NORBERTO;ROTA, STEFANIA;TAGLIABUE, ELENA;
2005
Abstract
Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
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