Computational models are expected to increase understanding of how complex biological functions arise from the interactions of large numbers of gene products and biologically active low molecular weight molecules. Recent studies underline the need to develop quantitative models of the whole cell in order to tackle this challenge and to accelerate biological discoveries. In this work we describe three major functions of a yeast cell: Metabolism, Growth and Cycle, through two coarse grain models, MeGro (Metabolism + Growth) and GroCy (Growth + Cycle). GroCy effectively recapitulates major phenotypic properties of cells grown in glucose and ethanol supplement media. MeGro can act as a parameter generator for GroCy. The resulting iMeGroCy integrated model can be used as a scaffold for molecularly detailed models of yeast functions.

Palumbo, P., Vanoni, M., Papa, F., Busti, S., Wortel, M., Teusink, B., et al. (2018). An integrated model quantitatively describing metabolism, growth and cell cycle in budding yeast. In M. Pelillo, I. Poli, A. Roli, R. Serra, D. Slanzi, M. Villani (a cura di), Artificial Life and Evolutionary Computation. 12th Italian Workshop, WIVACE 2017, Venice, Italy, September 19-21, 2017, Revised Selected Papers (pp. 165-180). Springer Verlag [10.1007/978-3-319-78658-2_13].

An integrated model quantitatively describing metabolism, growth and cell cycle in budding yeast

Palumbo P
Primo
;
Vanoni M
;
PAPA, FABRIZIO;Busti S;Alberghina L
2018

Abstract

Computational models are expected to increase understanding of how complex biological functions arise from the interactions of large numbers of gene products and biologically active low molecular weight molecules. Recent studies underline the need to develop quantitative models of the whole cell in order to tackle this challenge and to accelerate biological discoveries. In this work we describe three major functions of a yeast cell: Metabolism, Growth and Cycle, through two coarse grain models, MeGro (Metabolism + Growth) and GroCy (Growth + Cycle). GroCy effectively recapitulates major phenotypic properties of cells grown in glucose and ethanol supplement media. MeGro can act as a parameter generator for GroCy. The resulting iMeGroCy integrated model can be used as a scaffold for molecularly detailed models of yeast functions.
Capitolo o saggio
Computational models; Systems biology; Whole cell models;
Cell cycle, whole-cell-model
English
Artificial Life and Evolutionary Computation. 12th Italian Workshop, WIVACE 2017, Venice, Italy, September 19-21, 2017, Revised Selected Papers
Pelillo, M; Poli, I; Roli, A; Serra, R; Slanzi, D; Villani, M
2018
9783319786575
830
Springer Verlag
165
180
Palumbo, P., Vanoni, M., Papa, F., Busti, S., Wortel, M., Teusink, B., et al. (2018). An integrated model quantitatively describing metabolism, growth and cell cycle in budding yeast. In M. Pelillo, I. Poli, A. Roli, R. Serra, D. Slanzi, M. Villani (a cura di), Artificial Life and Evolutionary Computation. 12th Italian Workshop, WIVACE 2017, Venice, Italy, September 19-21, 2017, Revised Selected Papers (pp. 165-180). Springer Verlag [10.1007/978-3-319-78658-2_13].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/197910
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