Objective: In 55 prepubertal children with growth failure, aged 8.62 +/- 2.89 years, we evaluated the efficacy of a test using only half the usual dose of insulin by comparing the results with those obtained during a classical arginine tolerance test, performed separately. Patients and Methods: The patients were randomly divided into two groups: group A consisting of 37 children received 0.05 U/kg insulin, while group B consisting of 18 patients received 0.1 U/kg insulin. Each child received the same dose of arginine per kg during the second test. Results: Serum growth hormone (GH) peak levels were significantly (p <0.01) lower in children of group A (6.59 +/- 4.10 ng/ml) than in those of group B (10.12 +/- 5.80 ng/ml). No differences of GH peak levels were found in patients of the two groups after arginine infusion. The injection of 0.05 U/kg insulin induced a significantly (p <0.0001) lower percent decrease of serum glucose than 0.1 U/kg. No difference of the percent increase of serum cortisol induced by insulin at 0.05 U/kg and 0.1 U/kg was observed. Conclusion: The diagnosis of GH deficiency in children can be supported by a blunted GH response after two or more pharmacological stimuli including hypoglycaemia induced by only half the usual dose of insulin.

Bozzola, M., Comoli, P., Bozzola, E., Tinelli, C., Marello, A., Stabile, M., et al. (2005). Low dose of insulin for assessment of growth hormone and cortisol release in short children. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 18(8), 815-818 [10.1515/JPEM.2005.18.8.815].

Low dose of insulin for assessment of growth hormone and cortisol release in short children

LOCATELLI, VITTORIO
2005

Abstract

Objective: In 55 prepubertal children with growth failure, aged 8.62 +/- 2.89 years, we evaluated the efficacy of a test using only half the usual dose of insulin by comparing the results with those obtained during a classical arginine tolerance test, performed separately. Patients and Methods: The patients were randomly divided into two groups: group A consisting of 37 children received 0.05 U/kg insulin, while group B consisting of 18 patients received 0.1 U/kg insulin. Each child received the same dose of arginine per kg during the second test. Results: Serum growth hormone (GH) peak levels were significantly (p <0.01) lower in children of group A (6.59 +/- 4.10 ng/ml) than in those of group B (10.12 +/- 5.80 ng/ml). No differences of GH peak levels were found in patients of the two groups after arginine infusion. The injection of 0.05 U/kg insulin induced a significantly (p <0.0001) lower percent decrease of serum glucose than 0.1 U/kg. No difference of the percent increase of serum cortisol induced by insulin at 0.05 U/kg and 0.1 U/kg was observed. Conclusion: The diagnosis of GH deficiency in children can be supported by a blunted GH response after two or more pharmacological stimuli including hypoglycaemia induced by only half the usual dose of insulin.
Articolo in rivista - Articolo scientifico
growth hormone; growth hormone deficiency; insulin; cortisol; glycaemia; children
English
ago-2005
18
8
815
818
none
Bozzola, M., Comoli, P., Bozzola, E., Tinelli, C., Marello, A., Stabile, M., et al. (2005). Low dose of insulin for assessment of growth hormone and cortisol release in short children. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 18(8), 815-818 [10.1515/JPEM.2005.18.8.815].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/1973
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
Social impact