Background: Two therapeutic options are currently available for patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. To date, there is still insufficient data on the efficacy of these 2 agents in patients with more severe disease. Objectives: This national, multicenter, retrospective real-life study was intended to determine the impact of nintedanib on the treatment of patients with severe IPF. Methods: All patients included had severe IPF and had to have at least 6 months of follow-up before and at least 6 months of follow-up after starting nintedanib. The aim of the study was to compare the decline in lung function before and after treatment. Patient survival after 6 months of therapy with nintedanib was assessed. Results: Forty-one patients with a forced vital capacity (FVC) ≤50% and/or a diffusing capacity of the lung for carbon monoxide (DLCO) ≤35% predicted at the start of nintedanib treatment were enrolled. At the 6-month follow-up, the decline of DLCO (both absolute and % predicted) was significantly reduced compared to the pretreatment period (absolute DLCO at the -6-month, T0, and +6-month time points (5.48, 4.50, and 5.03 mmol/min/kPa, respectively, p = 0.03; DLCO% predicted was 32.73, 26.54, and 29.23%, respectively, p = 0.04). No significant beneficial effect was observed in the other functional parameters analyzed. The 1-year survival in this population was 79%, calculated from month 6 of therapy with nintedanib. Conclusions: This nationwide multicenter experience in patients with severe IPF shows that nintedanib slows down the rate of decline of absolute and % predicted DLCO but does not have significant impact on FVC or other lung parameters.
Harari, S., Caminati, A., Poletti, V., Confalonieri, M., Gasparini, S., Lacedonia, D., et al. (2018). A Real-Life Multicenter National Study on Nintedanib in Severe Idiopathic Pulmonary Fibrosis. RESPIRATION, 95(6), 433-440 [10.1159/000487711].
|Citazione:||Harari, S., Caminati, A., Poletti, V., Confalonieri, M., Gasparini, S., Lacedonia, D., et al. (2018). A Real-Life Multicenter National Study on Nintedanib in Severe Idiopathic Pulmonary Fibrosis. RESPIRATION, 95(6), 433-440 [10.1159/000487711].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||A Real-Life Multicenter National Study on Nintedanib in Severe Idiopathic Pulmonary Fibrosis|
|Autori:||Harari, S; Caminati, A; Poletti, V; Confalonieri, M; Gasparini, S; Lacedonia, D; Luppi, F; Pesci, A; Sebastiani, A; Spagnolo, P; Vancheri, C; Balestro, E; Bonifazi, M; Cerri, S; De Giacomi, F; Della Porta, R; Foschino Barbaro, M; Fui, A; Pasquinelli, P; Rosso, R; Tomassetti, S; Specchia, C; Rottoli, P|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000487711|
|Appare nelle tipologie:||01 - Articolo su rivista|