IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishBackground: Trial sequential analysis (TSA) may establish when firm evidence about the efficacy of interventions is reached in a cumulative meta-analysis, combining a required information size with adjusted thresholds for conservative statistical significance. Our aim was to demonstrate TSA results on randomized controlled trials (RCTs) included in a Cochrane systematic review on the effectiveness of constraint-induced movement therapy (CIMT) for stroke patients. Methods: We extracted data on the functional independence measure (FIM) and the action research arm test (ARAT) from RCTs that compared CIMT versus other rehabilitative techniques. Mean differences (MD) were analyzed using a random-effects model. We calculated the information size and the cumulative Z-statistic, applying the O'Brien-Fleming monitoring boundaries. Results: We included data from 14 RCTs. In the conventional meta-analysis (seven trials, 233 patients), the effect of CIMT on FIM was reported as significant (MD 2.88, 95% CI 0.08 to 5.68; P = 0.04). The diversity-adjusted required information size was 142 patients, and the cumulative Z-score did not cross the trial sequential monitoring boundary for benefit (adjusted 95% CI -0.02 to 5.78). The effect of CIMT on ARAT (nine trials, 199 patients) was reported as significant (MD 7.78, 95% CI 1.19 to 14.37; P = 0.02). However, the diversity-adjusted required information size was 252 patients, and the Z-score did not cross the trial sequential monitoring boundary for benefit (adjusted 95% CI -0.06 to 15.62). Conclusions: Although conventional meta-analyses of CIMT reached statistical significance, their overall results remain inconclusive and might be spurious. Researchers should not be overconfident on CIMT efficacy based on the results of meta-analyses and derived recommendations.
Castellini, G., Gianola, S., Banzi, R., Corbetta, D., Gatti, R., Sirtori, V., et al. (2014). Constraint-induced movement therapy: Trial sequential analysis applied to Cochrane collaboration systematic review results. TRIALS, 15(1), 512 [10.1186/1745-6215-15-512].
| Citazione: | Castellini, G., Gianola, S., Banzi, R., Corbetta, D., Gatti, R., Sirtori, V., et al. (2014). Constraint-induced movement therapy: Trial sequential analysis applied to Cochrane collaboration systematic review results. TRIALS, 15(1), 512 [10.1186/1745-6215-15-512]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | Constraint-induced movement therapy: Trial sequential analysis applied to Cochrane collaboration systematic review results | |
| Autori: | Castellini, G; Gianola, S; Banzi, R; Corbetta, D; Gatti, R; Sirtori, V; Gluud, C; Moja, L | |
| Autori: | ||
| Data di pubblicazione: | 2014 | |
| Lingua: | English | |
| Rivista: | TRIALS | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/1745-6215-15-512 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Castellini 2014.pdf | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/10281/193161
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