Background: The International Agency for Research on Cancer (IARC) concluded that alcohol consumption is related to colorectal cancer (CRC). However, several issues remain unresolved, including quantification of the association for light (£1 drink/day) and moderate (2–3 drinks/day) alcohol drinking, investigation of the dose–response relationship, and potential heterogeneity of effects by sex, colorectal site, and geographical region. Methods: Twenty-seven cohort and 34 case–control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before May 2010. The summary relative risks (RRs) were estimated by the random effects model. Second-order fractional polynomials and random effects metaregression models were used for modeling the dose–risk relation. Results: The RRs were 1.21 [95% confidence interval (CI) 1.13–1.28] for moderate and 1.52 (95% CI 1.27–1.81) for heavy (‡4 drinks/day) alcohol drinking. The RR for moderate drinkers, compared with non-/occasional drinkers, was stronger for men (RR = 1.24, 95% CI 1.13–1.37) than for women (RR = 1.08, 95% CI 1.03–1.13; Pheterogeneity = 0.02). For heavy drinkers, the association was stronger in Asian studies (RR = 1.81, 95% CI 1.33–2.46; Pheterogeneity = 0.04). The dose–risk analysis estimated RRs of 1.07 (95% CI 1.04–1.10), 1.38 (95% CI 1.28–1.50), and 1.82 (95% CI 1.41– 2.35) for 10, 50, and 100 g/day of alcohol, respectively. Conclusions: This meta-analysis provides strong evidence for an association between alcohol drinking of >1 drink/ day and colorectal cancer risk.
Fedirko, V., Tramacere, I., Bagnardi, V., Rota, M., Scotti, L., Islami, F., et al. (2011). Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. ANNALS OF ONCOLOGY, 22(9), 1958-1972 [10.1093/annonc/mdq653].
|Citazione:||Fedirko, V., Tramacere, I., Bagnardi, V., Rota, M., Scotti, L., Islami, F., et al. (2011). Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. ANNALS OF ONCOLOGY, 22(9), 1958-1972 [10.1093/annonc/mdq653].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies|
|Autori:||Fedirko, V; Tramacere, I; Bagnardi, V; Rota, M; Scotti, L; Islami, F; Negri, E; Straif, K; Romieu, I; La Vecchia, C; Boffetta, P; Jenab, M|
|Data di pubblicazione:||2011|
|Rivista:||ANNALS OF ONCOLOGY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/annonc/mdq653|
|Appare nelle tipologie:||01 - Articolo su rivista|