The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.

Barbero, F., Russo, L., Vitali, M., Piella, J., Salvo, I., Borrajo, M., et al. (2017). Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System. SEMINARS IN IMMUNOLOGY, 34(December), 52-60 [10.1016/j.smim.2017.10.001].

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Vitali, M;Grandori, R;
2017

Abstract

The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.
Articolo in rivista - Review Essay
Homo and Hetero-aggregation; Immune Response; Inorganic Nanoparticles; Nanoparticle-Protein Corona; Protein Corona Characterization; Vroman Effect; Immunology and Allergy; Immunology
English
2017
34
December
52
60
reserved
Barbero, F., Russo, L., Vitali, M., Piella, J., Salvo, I., Borrajo, M., et al. (2017). Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System. SEMINARS IN IMMUNOLOGY, 34(December), 52-60 [10.1016/j.smim.2017.10.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/189023
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