Objectives: The impact of chronic liver diseases (CLDs) on health-related quality of life (HRQoL) is relevant to understand the burden of these conditions and to inform decision-making processes. Exhaustive studies addressing simultaneously all major CLDs are still lacking, therefore we compared HRQoL of patients affected by major CLDs with that of the general population. Methods: We analyzed HRQoL data of Italian patients with major CLDs with those of a representative sample of the general Italian population. HRQoL data were collected using the EQ-5D-3L. In order to assess the association between each CLD and HRQoL, we performed multiple regression analyses, adjusting for possible confounders, using each domain of the EQ-5D descriptive system, the utility index and the visual analogue scale (VAS) as dependent variables. Results: Overall, data from 2,962 subjects with CLDs and from 6,800 individuals from the general population were analyzed. Advanced CLDs (decompensated cirrhosis and HCC) were associated with a significantly higher risk of reporting problems in physical domains(mobility, self-care and usual activity), autoimmune hepatitis in self-care, and hepatitis-C and NAFLD/NASH in anxiety/depression. Similar results were obtained with VAS and utility index: advanced CLDs were associated with a significant reduction in both indexes, while autoimmune hepatitis reduced only VAS score. Conclusions: HRQoL in early stage of CLDs is similar to the general population and it decreases with the progression to advanced stages. This study presents a real estimate of the impact of major CLDs on patients’ HRQoL, providing a key tool for decision-making in care delivery for CLDs. Key messages: Quality of life in early stage of chronic livers diseases is similar to the general population and lower in advanced stages. Our results providing a key tool for decision-making in care delivery

Cortesi, P., Conti, S., Scalone, L., Ciaccio, A., Okolicsanyi, S., Rota, M., et al. (2017). Difference in health related quality of life of chronic liver diseases and general population. EUROPEAN JOURNAL OF PUBLIC HEALTH, 27(Suppl 3), 31-31 [10.1093/eurpub/ckx187.078].

Difference in health related quality of life of chronic liver diseases and general population

Cortesi, PA;Conti, S;Scalone, L;Ciaccio, A;Okolicsanyi, S;Rota, M;Cesana, G;Strazzabosco, M;Mantovani, LG
2017

Abstract

Objectives: The impact of chronic liver diseases (CLDs) on health-related quality of life (HRQoL) is relevant to understand the burden of these conditions and to inform decision-making processes. Exhaustive studies addressing simultaneously all major CLDs are still lacking, therefore we compared HRQoL of patients affected by major CLDs with that of the general population. Methods: We analyzed HRQoL data of Italian patients with major CLDs with those of a representative sample of the general Italian population. HRQoL data were collected using the EQ-5D-3L. In order to assess the association between each CLD and HRQoL, we performed multiple regression analyses, adjusting for possible confounders, using each domain of the EQ-5D descriptive system, the utility index and the visual analogue scale (VAS) as dependent variables. Results: Overall, data from 2,962 subjects with CLDs and from 6,800 individuals from the general population were analyzed. Advanced CLDs (decompensated cirrhosis and HCC) were associated with a significantly higher risk of reporting problems in physical domains(mobility, self-care and usual activity), autoimmune hepatitis in self-care, and hepatitis-C and NAFLD/NASH in anxiety/depression. Similar results were obtained with VAS and utility index: advanced CLDs were associated with a significant reduction in both indexes, while autoimmune hepatitis reduced only VAS score. Conclusions: HRQoL in early stage of CLDs is similar to the general population and it decreases with the progression to advanced stages. This study presents a real estimate of the impact of major CLDs on patients’ HRQoL, providing a key tool for decision-making in care delivery for CLDs. Key messages: Quality of life in early stage of chronic livers diseases is similar to the general population and lower in advanced stages. Our results providing a key tool for decision-making in care delivery
Abstract in rivista
chronic liver disease; quality of life
English
1-nov-2017
2017
27
Suppl 3
31
31
none
Cortesi, P., Conti, S., Scalone, L., Ciaccio, A., Okolicsanyi, S., Rota, M., et al. (2017). Difference in health related quality of life of chronic liver diseases and general population. EUROPEAN JOURNAL OF PUBLIC HEALTH, 27(Suppl 3), 31-31 [10.1093/eurpub/ckx187.078].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/186829
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