Background: Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) mediated pathological processes that play key roles in Alzheimer’s disease (AD) pathogenesis. Research design and methods: Multiple complementary assays were used to investigate individual SCFAs for their dose-responsive effects in interfering with the assembly of Aβß1-40 and Aβ1-42 peptides into soluble neurotoxic Aβ aggregates. Results: We found that several select SCFAs are capable of potently inhibiting Aβ aggregations, in vitro. Conclusion: Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates
Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., Pasinetti, G. (2018). Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimerâ s disease-type beta-amyloid neuropathological mechanisms. EXPERT REVIEW OF NEUROTHERAPEUTICS, 18(1), 83-90 [10.1080/14737175.2018.1400909].
Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimerâs disease-type beta-amyloid neuropathological mechanisms
Mazzola, P;
2018
Abstract
Background: Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) mediated pathological processes that play key roles in Alzheimer’s disease (AD) pathogenesis. Research design and methods: Multiple complementary assays were used to investigate individual SCFAs for their dose-responsive effects in interfering with the assembly of Aβß1-40 and Aβ1-42 peptides into soluble neurotoxic Aβ aggregates. Results: We found that several select SCFAs are capable of potently inhibiting Aβ aggregations, in vitro. Conclusion: Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates
| File | Dimensione | Formato | |
|---|---|---|---|
|
Protective roles of intestinal microbiota in AD-Exp Rev Neurother 2017.pdf
Accesso Aperto
Descrizione: Articolo principale
Dimensione
1.64 MB
Formato
Adobe PDF
|
1.64 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
