Repolarization response to β-adrenergic (β-AR) stimulation differs between guinea-pig and canine myocytes and, within the latter, between myocardial layers. Correlative analysis suggests that this may be due to differences in action potential (AP) contour. Here we tested whether AP contour may set the response of current and of repolarization to β-AR stimulation (10 nM isoproterenol, ISO).
Sala, L., Hegyi, B., Bartolucci, C., Altomare, C., Rocchetti, M., Váczi, K., et al. (2018). Action potential contour contributes to species differences in repolarization response to b-adrenergic stimulation. EUROPACE, 20(9), 1543-1552 [10.1093/europace/eux236].
Action potential contour contributes to species differences in repolarization response to b-adrenergic stimulation
Sala, L;Altomare, C;Rocchetti, M;Mostacciuolo, G;Zaza, A
2018
Abstract
Repolarization response to β-adrenergic (β-AR) stimulation differs between guinea-pig and canine myocytes and, within the latter, between myocardial layers. Correlative analysis suggests that this may be due to differences in action potential (AP) contour. Here we tested whether AP contour may set the response of current and of repolarization to β-AR stimulation (10 nM isoproterenol, ISO).
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