Repolarization response to β-adrenergic (β-AR) stimulation differs between guinea-pig and canine myocytes and, within the latter, between myocardial layers. Correlative analysis suggests that this may be due to differences in action potential (AP) contour. Here we tested whether AP contour may set the response of current and of repolarization to β-AR stimulation (10 nM isoproterenol, ISO).

Sala, L., Hegyi, B., Bartolucci, C., Altomare, C., Rocchetti, M., Váczi, K., et al. (2018). Action potential contour contributes to species differences in repolarization response to b-adrenergic stimulation. EUROPACE, 20(9), 1543-1552 [10.1093/europace/eux236].

Action potential contour contributes to species differences in repolarization response to b-adrenergic stimulation

Altomare, C;Rocchetti, M;Mostacciuolo, G;Zaza, A
2018

Abstract

Repolarization response to β-adrenergic (β-AR) stimulation differs between guinea-pig and canine myocytes and, within the latter, between myocardial layers. Correlative analysis suggests that this may be due to differences in action potential (AP) contour. Here we tested whether AP contour may set the response of current and of repolarization to β-AR stimulation (10 nM isoproterenol, ISO).
Articolo in rivista - Articolo scientifico
Adrenergic stimulation; Cardiac arrhythmias; Dynamic clamp; Electrophysiology; Repolarization;
Adrenergic stimulation; Cardiac arrhythmias; Dynamic clamp; Electrophysiology; Repolarization
English
1543
1552
10
Sala, L., Hegyi, B., Bartolucci, C., Altomare, C., Rocchetti, M., Váczi, K., et al. (2018). Action potential contour contributes to species differences in repolarization response to b-adrenergic stimulation. EUROPACE, 20(9), 1543-1552 [10.1093/europace/eux236].
Sala, L; Hegyi, B; Bartolucci, C; Altomare, C; Rocchetti, M; Váczi, K; Mostacciuolo, G; Szentandrássy, N; Severi, S; Pál Nánási, P; Zaza, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/185718
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