Background:Because of their antioxidant and antimutagenic properties, flavonoids may reduce cancer risk. Some flavonoids have antiestrogenic effects that can inhibit the growth and proliferation of endometrial cancer cells.Methods:In order to examine the relation between dietary flavonoids and endometrial cancer, we analysed data from an Italian case-control study including 454 incident, histologically confirmed endometrial cancers and 908 hospital-based controls. Information was collected through a validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of flavanols, flavanones, flavonols, anthocyanidins, flavones, isoflavones, and proanthocyanidins. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multiple logistic regression models conditioned on age and study centre and adjusted for major confounding factors.Results:Women in the highest quartile category of proanthocyanidins with ≥3 mers vs the first three quartile categories had an OR for endometrial cancer of 0.66 (95% CI=0.48-0.89). For no other class of flavonoids, a significant overall association was found. There was a suggestion of an inverse association for flavanones and isoflavones among women with body mass index <25 kg m-2, and, for flavanones, among parous or non-users of hormone-replacement therapy women.Conclusion:High consumption of selected proanthocyanidins may reduce endometrial cancer risk

Rossi, M., Edefonti, V., Parpinel, M., Lagiou, P., Franchi, M., Ferraroni, M., et al. (2013). Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: A case-control study in Italy. BRITISH JOURNAL OF CANCER, 109(7), 1914-1920 [10.1038/bjc.2013.447].

Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: A case-control study in Italy

Franchi, M;Decarli, A;
2013

Abstract

Background:Because of their antioxidant and antimutagenic properties, flavonoids may reduce cancer risk. Some flavonoids have antiestrogenic effects that can inhibit the growth and proliferation of endometrial cancer cells.Methods:In order to examine the relation between dietary flavonoids and endometrial cancer, we analysed data from an Italian case-control study including 454 incident, histologically confirmed endometrial cancers and 908 hospital-based controls. Information was collected through a validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of flavanols, flavanones, flavonols, anthocyanidins, flavones, isoflavones, and proanthocyanidins. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multiple logistic regression models conditioned on age and study centre and adjusted for major confounding factors.Results:Women in the highest quartile category of proanthocyanidins with ≥3 mers vs the first three quartile categories had an OR for endometrial cancer of 0.66 (95% CI=0.48-0.89). For no other class of flavonoids, a significant overall association was found. There was a suggestion of an inverse association for flavanones and isoflavones among women with body mass index <25 kg m-2, and, for flavanones, among parous or non-users of hormone-replacement therapy women.Conclusion:High consumption of selected proanthocyanidins may reduce endometrial cancer risk
Articolo in rivista - Articolo scientifico
diet; endometrial cancer; flavonoids; proanthocyanidins; risk; Adolescent; Adult; Aged; Anthocyanins; Case-Control Studies; Endometrial Neoplasms; Female; Flavanones; Flavones; Flavonols; Humans; Isoflavones; Italy; Middle Aged; Proanthocyanidins; Risk Factors; Surveys and Questionnaires; Young Adult; Feeding Behavior; Oncology; Cancer Research
English
2013
109
7
1914
1920
none
Rossi, M., Edefonti, V., Parpinel, M., Lagiou, P., Franchi, M., Ferraroni, M., et al. (2013). Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: A case-control study in Italy. BRITISH JOURNAL OF CANCER, 109(7), 1914-1920 [10.1038/bjc.2013.447].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/185498
Citazioni
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 28
Social impact