A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.

Quattrini, A., Comi, G., Nemni, R., Martinelli, V., Villa, A., Caimi, M., et al. (1997). Axonal neuropathy associated with interferon-alpha treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells. ACTA NEUROPATHOLOGICA, 94(5), 504-508 [10.1007/s004010050740].

Axonal neuropathy associated with interferon-alpha treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells

VILLA, ANTONELLO;
1997

Abstract

A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
Articolo in rivista - Articolo scientifico
Axons; HLA-DR Antigens; Male; Immunohistochemistry; Peripheral Nervous System Diseases; Sural Nerve; Humans; Neural Conduction; Schwann Cells; Fluorescent Antibody Technique, Direct; Nerve Fibers, Myelinated; Interferon Type I, Recombinant; Adult; Hepatitis C
English
nov-1997
94
5
504
508
none
Quattrini, A., Comi, G., Nemni, R., Martinelli, V., Villa, A., Caimi, M., et al. (1997). Axonal neuropathy associated with interferon-alpha treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells. ACTA NEUROPATHOLOGICA, 94(5), 504-508 [10.1007/s004010050740].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/18541
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