New enantiomerically enriched 1,4,5-piperazines and 1,4,5-dihydro-2H-pyrazines have been prepared by reduction of the corresponding 2-oxo-piperazines. Selective reduction can be achieved by careful control of the reaction conditions using LiAlH4. Notably the two nitrogen atoms of the final compounds are orthogonally protected. © 2010 Elsevier Ltd. All rights reserved

Reginato, G., Di Credico, B., Andreotti, D., Mingardi, A., Paio, A., Donati, D., et al. (2010). Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines. TETRAHEDRON-ASYMMETRY, 21(2), 191-194 [10.1016/j.tetasy.2009.12.025].

Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines

Di Credico, B;
2010

Abstract

New enantiomerically enriched 1,4,5-piperazines and 1,4,5-dihydro-2H-pyrazines have been prepared by reduction of the corresponding 2-oxo-piperazines. Selective reduction can be achieved by careful control of the reaction conditions using LiAlH4. Notably the two nitrogen atoms of the final compounds are orthogonally protected. © 2010 Elsevier Ltd. All rights reserved
Articolo in rivista - Articolo scientifico
Catalysis; Inorganic Chemistry; Organic Chemistry; Physical and Theoretical Chemistry;
English
2010
21
2
191
194
none
Reginato, G., Di Credico, B., Andreotti, D., Mingardi, A., Paio, A., Donati, D., et al. (2010). Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines. TETRAHEDRON-ASYMMETRY, 21(2), 191-194 [10.1016/j.tetasy.2009.12.025].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/184663
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