Intraocular lenses can be manufactured from a wide variety of polymers, but due to the lost cost associated with the use of Poly(methyl methacrylate) (PMMA), it is still the preferred material used in the developing countries. However, a major drawback to its use is the build-up of calcium containing deposits that are formed on the intraocular lens over a period of time. In an attempt to hinder this deposition, surface modification of medical grade PMMA has been carried out using perfluoroalkyl chain (1,2,4-trifluoro-3- (C10F21CH2O)-7-(N,N)-dimethylaminoacridine) segregation. The segregation was explored using a 1% 1,2,4-trifluoro-3-(C10F21CH2O)-7-(N,N)-dimethylaminoacridine in two methods: film casting and spin-coating, a thin film onto preformed PMMA discs. Both methods were compared against control PMMA to determine which method provided the best hindrance against calcium containing deposits when immersed in a simulated aqueous humour solution. Characterisation of the surface using scanning electron microscopy coupled with energy; dispersive x-ray analysis indicated that the surface segregation of perfluoroalkyl chains had hindered calcification in both methods. This pleminary research shows promising results of employing perfluoroalkyl chains in the surface segregation of biomaterials that can be employed in intraocular lenses.

Ghatora, B., Foot, P., Barton, S., Thatti, R., Papagni, A., Vaghi, L. (2017). Surface Perfluoroalkyl Chains Segregation: A Tool for Reducing Calcium Deposits in Medical Grade Poly(Methyl Methacrylate). JOURNAL OF BIOMATERIALS AND NANOBIOTECHNOLOGY, 08(02), 176-187 [10.4236/jbnb.2017.82012].

Surface Perfluoroalkyl Chains Segregation: A Tool for Reducing Calcium Deposits in Medical Grade Poly(Methyl Methacrylate)

Papagni, A;Vaghi, L
2017

Abstract

Intraocular lenses can be manufactured from a wide variety of polymers, but due to the lost cost associated with the use of Poly(methyl methacrylate) (PMMA), it is still the preferred material used in the developing countries. However, a major drawback to its use is the build-up of calcium containing deposits that are formed on the intraocular lens over a period of time. In an attempt to hinder this deposition, surface modification of medical grade PMMA has been carried out using perfluoroalkyl chain (1,2,4-trifluoro-3- (C10F21CH2O)-7-(N,N)-dimethylaminoacridine) segregation. The segregation was explored using a 1% 1,2,4-trifluoro-3-(C10F21CH2O)-7-(N,N)-dimethylaminoacridine in two methods: film casting and spin-coating, a thin film onto preformed PMMA discs. Both methods were compared against control PMMA to determine which method provided the best hindrance against calcium containing deposits when immersed in a simulated aqueous humour solution. Characterisation of the surface using scanning electron microscopy coupled with energy; dispersive x-ray analysis indicated that the surface segregation of perfluoroalkyl chains had hindered calcification in both methods. This pleminary research shows promising results of employing perfluoroalkyl chains in the surface segregation of biomaterials that can be employed in intraocular lenses.
Articolo in rivista - Articolo scientifico
Poly(Methyl Methacrylate) (PMMA), Perfluoroalkyl, Segregation, Medical Polymers, Wettability, Calcium Deposits
English
176
187
12
Ghatora, B., Foot, P., Barton, S., Thatti, R., Papagni, A., Vaghi, L. (2017). Surface Perfluoroalkyl Chains Segregation: A Tool for Reducing Calcium Deposits in Medical Grade Poly(Methyl Methacrylate). JOURNAL OF BIOMATERIALS AND NANOBIOTECHNOLOGY, 08(02), 176-187 [10.4236/jbnb.2017.82012].
Ghatora, B; Foot, P; Barton, S; Thatti, R; Papagni, A; Vaghi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/184330
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