Various aspects of the rapidly exchanging intracellular Ca2+ stores of neurons and nerve cells are reviewed: their multiplicity, with separate sensitivity to either the second messenger, inositol 1,4,5-trisphosphate, or ryanodine-caffeine (the latter stores are probably activated via Ca(2+)-induced Ca2+ release); their control of the plasma membrane Ca2+ permeability, via the activation of a peculiar type of cation channels; their ability to sustain localized heterogeneities of the [Ca2+]i that could be of physiological key-importance. Finally, the molecular composition of these stores is discussed. They are shown (by high resolution immunocytochemistry and subcellular fractionation) to express: i) a Ca2+ ATPase responsible for the accumulation of the cation; ii) Ca2+ binding protein(s) of low affinity and high capacity to keep Ca2+ stored; and iii) a Ca2+ channel, activated by either one of the mechanisms mentioned above, to release Ca2+ to the cytosol. Results obtained in Purkinje neurons document the heterogeneity of the stores and the strategical distribution of the corresponding organelles (calciosomes; specialized portions of the ER) within the cell body, dendrites and dendritic spines.
Meldolesi, J., Villa, A., Podini, P., Clementi, E., Zacchetti, D., D'Andrea, P., et al. (1992). Intracellular Ca2+ stores in neurons. Identification and functional aspects. JOURNAL OF PHYSIOLOGY, 86(1-3), 23-30.
Citazione: | Meldolesi, J., Villa, A., Podini, P., Clementi, E., Zacchetti, D., D'Andrea, P., et al. (1992). Intracellular Ca2+ stores in neurons. Identification and functional aspects. JOURNAL OF PHYSIOLOGY, 86(1-3), 23-30. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Titolo: | Intracellular Ca2+ stores in neurons. Identification and functional aspects | |
Autori: | Meldolesi, J; Villa, A; Podini, P; Clementi, E; Zacchetti, D; D'Andrea, P; Lorenzon, P; Grohovaz, F | |
Autori: | ||
Data di pubblicazione: | 1992 | |
Lingua: | English | |
Rivista: | JOURNAL OF PHYSIOLOGY | |
Appare nelle tipologie: | 01 - Articolo su rivista |