Various aspects of the rapidly exchanging intracellular Ca2+ stores of neurons and nerve cells are reviewed: their multiplicity, with separate sensitivity to either the second messenger, inositol 1,4,5-trisphosphate, or ryanodine-caffeine (the latter stores are probably activated via Ca(2+)-induced Ca2+ release); their control of the plasma membrane Ca2+ permeability, via the activation of a peculiar type of cation channels; their ability to sustain localized heterogeneities of the [Ca2+]i that could be of physiological key-importance. Finally, the molecular composition of these stores is discussed. They are shown (by high resolution immunocytochemistry and subcellular fractionation) to express: i) a Ca2+ ATPase responsible for the accumulation of the cation; ii) Ca2+ binding protein(s) of low affinity and high capacity to keep Ca2+ stored; and iii) a Ca2+ channel, activated by either one of the mechanisms mentioned above, to release Ca2+ to the cytosol. Results obtained in Purkinje neurons document the heterogeneity of the stores and the strategical distribution of the corresponding organelles (calciosomes; specialized portions of the ER) within the cell body, dendrites and dendritic spines.
Meldolesi, J., Villa, A., Podini, P., Clementi, E., Zacchetti, D., D'Andrea, P., et al. (1992). Intracellular Ca2+ stores in neurons. Identification and functional aspects. JOURNAL OF PHYSIOLOGY, 86(1-3), 23-30.
|Citazione:||Meldolesi, J., Villa, A., Podini, P., Clementi, E., Zacchetti, D., D'Andrea, P., et al. (1992). Intracellular Ca2+ stores in neurons. Identification and functional aspects. JOURNAL OF PHYSIOLOGY, 86(1-3), 23-30.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||Intracellular Ca2+ stores in neurons. Identification and functional aspects|
|Autori:||Meldolesi, J; Villa, A; Podini, P; Clementi, E; Zacchetti, D; D'Andrea, P; Lorenzon, P; Grohovaz, F|
|Data di pubblicazione:||1992|
|Rivista:||JOURNAL OF PHYSIOLOGY|
|Appare nelle tipologie:||01 - Articolo su rivista|