Background: We sought to investigate left ventricular (LV) function and mechanics in patients with cancer before they received chemotherapy or radiotherapy, as well as the relationship between cancer and reduced LV multidirectional strain in the whole study population. Methods: The retrospective study involved 122 chemotherapy- and radiotherapy-naive patients with cancer and 45 age- and sex-matched controls with a cardiovascular risk profile similar to that of the patients with cancer. All the patients underwent echocardiographic examination before introduction of chemotherapy or radiotherapy. Results: LV longitudinal (−19.1% ± 2.1% vs −17.8% ± 3.5%; P = 0.022), circumferential (−22.9% ± 3.5% vs −20.1% ± 4.1%; P < 0.001), and radial (40.5% ± 8.8% vs 35.2% ± 10.7%; P = 0.004) strain was significantly lower in the patients with cancer than in the control group. Endocardial and midmyocardial longitudinal LV strain was significantly reduced in the patients with cancer compared with the controls, whereas epicardial longitudinal strain was similar between these groups. Endocardial, midmyocardial, and epicardial circumferential strain was significantly lower in the chemotherapy- or radiotherapy-naive patients with cancer than in the controls. Cancer was associated with reduced longitudinal (odds ratio [OR], 9.0; 95% confidence interval [CI], 2.20-23.50; P < 0.001), reduced circumferential (OR, 7.1; 95% CI, 3.80-20.40; P < 0.001), and reduced radial strain (OR, 7.2; 95% CI, 3.41-25.10; P < 0.001) independent of age, sex, body mass index, diabetes, and hypertension. Conclusions: LV mechanics was impaired in the patients with cancer compared with the controls even before initiation of chemotherapy and radiotherapy. Cancer and hypertension were associated with reduced LV multidirectional strain independent of other clinical parameters. The present results indicate that cancer itself potentially induces cardiac remodelling independent of chemotherapy and radiotherapy.
Tadic, M., Genger, M., Baudisch, A., Kelle, S., Cuspidi, C., Belyavskiy, E., et al. (2018). Left Ventricular Strain in Chemotherapy-Naive and Radiotherapy-Naive Patients With Cancer. CANADIAN JOURNAL OF CARDIOLOGY, 34(3), 281-287 [10.1016/j.cjca.2017.11.018].
|Citazione:||Tadic, M., Genger, M., Baudisch, A., Kelle, S., Cuspidi, C., Belyavskiy, E., et al. (2018). Left Ventricular Strain in Chemotherapy-Naive and Radiotherapy-Naive Patients With Cancer. CANADIAN JOURNAL OF CARDIOLOGY, 34(3), 281-287 [10.1016/j.cjca.2017.11.018].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Left Ventricular Strain in Chemotherapy-Naive and Radiotherapy-Naive Patients With Cancer|
|Autori:||Tadic, M; Genger, M; Baudisch, A; Kelle, S; Cuspidi, C; Belyavskiy, E; Burkhardt, F; Venneri, L; Attanasio, P; Pieske, B|
|Data di pubblicazione:||2018|
|Rivista:||CANADIAN JOURNAL OF CARDIOLOGY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.cjca.2017.11.018|
|Appare nelle tipologie:||01 - Articolo su rivista|