Cells are never more vulnerable than during DNA replication, which represents a major moment of potential genetic instability. Genotoxic insults induce many different forms of DNA damage that may interfere with the ability of cells to properly duplicate their genome. Primary damage may in turn undergo structural transformations during DNA replication, thus generating secondary lesions that may be even more dangerous. Cells experiencing replication of damaged DNA or replication blocks activate an S-phase checkpoint response that assures the fidelity and completion of DNA replication before cells enter M-phase. The S-phase checkpoint pathway regulates not only progress through the cell cycle but also DNA repair and DNA replication itself.

Longhese, M., Clerici, M., Lucchini, G. (2003). The S-phase checkpoint and its regulation in Saccharomyces cerevisiae. MUTATION RESEARCH, 532(1-2), 41-58 [10.1016/j.mrfmmm.2003.08.009].

The S-phase checkpoint and its regulation in Saccharomyces cerevisiae

LONGHESE, MARIA PIA;CLERICI, MICHELA;LUCCHINI, GIOVANNA
2003

Abstract

Cells are never more vulnerable than during DNA replication, which represents a major moment of potential genetic instability. Genotoxic insults induce many different forms of DNA damage that may interfere with the ability of cells to properly duplicate their genome. Primary damage may in turn undergo structural transformations during DNA replication, thus generating secondary lesions that may be even more dangerous. Cells experiencing replication of damaged DNA or replication blocks activate an S-phase checkpoint response that assures the fidelity and completion of DNA replication before cells enter M-phase. The S-phase checkpoint pathway regulates not only progress through the cell cycle but also DNA repair and DNA replication itself.
Articolo in rivista - Articolo scientifico
Checkpoints; DNA damage; DNA repair; DNA replication
English
2003
532
1-2
41
58
none
Longhese, M., Clerici, M., Lucchini, G. (2003). The S-phase checkpoint and its regulation in Saccharomyces cerevisiae. MUTATION RESEARCH, 532(1-2), 41-58 [10.1016/j.mrfmmm.2003.08.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/1824
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