Study Objective: To evaluate the added value of the fluorescence dye indocyanine green (ICG) for sentinel lymph node (SLN) mapping in women with cervical cancer who had undergone previous conization (stage 1A-1B1) by comparing ICG versus Tc99mradiotracer + blue dye (BD). Design: Retrospective study (Canadian Task Force classification II-2). Setting: Two European academic medical centers, San Gerardo Hospital, Italy and University of Berne, Switzerland. Patients: Sixty-five women with early stage (IA-IB1) cervical cancer who had undergone previous conization and who underwent SLN mapping with Tc99m± BD (n = 23) or ICG (n = 42) followed by pelvic lymphadenectomy and fertility-sparing surgery or hysterectomy were included in this analysis. Intervention: Overall detection rate and bilateral SLN mapping rates of ICG were compared with those obtained using the standard Tc99mradiocolloid and BD. Measurement and Main Results: Overall, 220 SLNs were detected. The median number of SLNs per patient in the Tc99m± BD group was 2 (range, 1-5) and in the ICG group, 3 (range, 2-15). The detection rate of SLNs was 95.7% in Tc99m± BD group and 100% in the ICG group (p = .354). The women injected with ICG had a higher rate of bilateral mapping of the SLNs as compared with the Tc99m± BD group (95.2% vs 69.6%, p = .016%). Only 12% of the patients (8/65) presented metastatic nodes, 2 in the Tc99m± BD group and 6 in the ICG group. Conclusion: In early-stage cervical cancer patients conization had no significant impact on the SLN detection rate using both techniques (ICG and radiotracer ± BD). In this scenario a higher bilateral mapping rate was confirmed using the fluorescent dye ICG rather than the standard techniques

Buda, A., Papadia, A., Di Martino, G., Imboden, S., Bussi, B., Guerra, L., et al. (2018). Real-Time Fluorescent Sentinel Lymph Node Mapping with Indocyanine Green in Women with Previous Conization Undergoing Laparoscopic Surgery for Early Invasive Cervical Cancer: Comparison with Radiotracer ± Blue Dye. JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 25(3), 455-460 [10.1016/j.jmig.2017.10.002].

Real-Time Fluorescent Sentinel Lymph Node Mapping with Indocyanine Green in Women with Previous Conization Undergoing Laparoscopic Surgery for Early Invasive Cervical Cancer: Comparison with Radiotracer ± Blue Dye

Buda, Alessandro
Primo
;
Di Martino, Giampaolo;Guerra, Luca;De Ponti, Elena;Crivellaro, Cinzia
Penultimo
;
2018

Abstract

Study Objective: To evaluate the added value of the fluorescence dye indocyanine green (ICG) for sentinel lymph node (SLN) mapping in women with cervical cancer who had undergone previous conization (stage 1A-1B1) by comparing ICG versus Tc99mradiotracer + blue dye (BD). Design: Retrospective study (Canadian Task Force classification II-2). Setting: Two European academic medical centers, San Gerardo Hospital, Italy and University of Berne, Switzerland. Patients: Sixty-five women with early stage (IA-IB1) cervical cancer who had undergone previous conization and who underwent SLN mapping with Tc99m± BD (n = 23) or ICG (n = 42) followed by pelvic lymphadenectomy and fertility-sparing surgery or hysterectomy were included in this analysis. Intervention: Overall detection rate and bilateral SLN mapping rates of ICG were compared with those obtained using the standard Tc99mradiocolloid and BD. Measurement and Main Results: Overall, 220 SLNs were detected. The median number of SLNs per patient in the Tc99m± BD group was 2 (range, 1-5) and in the ICG group, 3 (range, 2-15). The detection rate of SLNs was 95.7% in Tc99m± BD group and 100% in the ICG group (p = .354). The women injected with ICG had a higher rate of bilateral mapping of the SLNs as compared with the Tc99m± BD group (95.2% vs 69.6%, p = .016%). Only 12% of the patients (8/65) presented metastatic nodes, 2 in the Tc99m± BD group and 6 in the ICG group. Conclusion: In early-stage cervical cancer patients conization had no significant impact on the SLN detection rate using both techniques (ICG and radiotracer ± BD). In this scenario a higher bilateral mapping rate was confirmed using the fluorescent dye ICG rather than the standard techniques
Articolo in rivista - Articolo scientifico
Blue dye; Cervical cancer; Fluorescent real-time mapping; Indocyanine green; Radiocolloid; Sentinel lymph node; Obstetrics and Gynecology
English
455
460
6
Buda, A., Papadia, A., Di Martino, G., Imboden, S., Bussi, B., Guerra, L., et al. (2018). Real-Time Fluorescent Sentinel Lymph Node Mapping with Indocyanine Green in Women with Previous Conization Undergoing Laparoscopic Surgery for Early Invasive Cervical Cancer: Comparison with Radiotracer ± Blue Dye. JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 25(3), 455-460 [10.1016/j.jmig.2017.10.002].
Buda, A; Papadia, A; Di Martino, G; Imboden, S; Bussi, B; Guerra, L; De Ponti, E; Reato, C; Gasparri, M; Crivellaro, C; Mueller, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/179963
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