Background: The contribution of monocyte activation in the development of HIV-associated neurocognitive disorders is not completely understood. This study aimed to explore the predictive value of peripheral monocyte/macrophage (M/M) phenotypes on the evolution of cognitive performance in a population of virologically suppressed HIV-infected patients. Setting: Prospective, observational, longitudinal study. Methods: HIV-1-infected patients with HIV-RNA <50copies/mL for >12 months underwent neuropsychological examination at baseline and after 1 year. Cognitive performance was evaluated using Z-transformed scores, and neurocognitive impairment (NCI) was defined according to Frascati criteria. Peripheral M/M phenotypes (classic CD14 ++ CD16 -, intermediate CD14 ++ CD16 +, and nonclassic CD14 + CD16 ++) and specific surface activation markers (eg, CD163, CD11b, and CD38) were evaluated using flow cytometry at baseline. Predictive value of peripheral M/M phenotypes on the evolution of cognitive performance over 1-year follow-up was also evaluated. Results: Overall, 54 patients [85.2% men, median age 50 years (range 27-60 years), 27.8% hepatitis C virus coinfected, 48.1% with past AIDS-defining events, median nadir CD4 83 cells/L (range 1-334), median baseline CD4 547 cells/L (range 136-1652)] were enrolled. Proportion of patients with NCI was low, accounting for 13% at baseline and 16.5% after 1 year (P = 0.687). Memory was the only single domain in which decreased performance after 1 year was observed (-0.25 Z-score, P = 0.025). In patients with significant decrease (≥0.5 SD) in memory performance (n = 20), significantly lower CD14 ++ CD16 + CD163 + (% CD14 ++ CD16 +) (P = 0.038) and higher CD14 + CD38 + (% CD14 +) (P = 0.030) levels were observed. Conclusions: In virologically suppressed HIV-infected patients, the evolution of memory performance could be linked to the expression of certain peripheral activated M/M phenotypes. Such associations should be verified in larger populations over the long term.
Fabbiani, M., Muscatello, A., Perseghin, P., Bani, M., Incontri, A., Squillace, N., et al. (2017). Brief Report: Peripheral Monocyte/Macrophage Phenotypes Associated with the Evolution of Cognitive Performance in HIV-Infected Patients. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 76(2), 219-224 [10.1097/QAI.0000000000001480].
|Citazione:||Fabbiani, M., Muscatello, A., Perseghin, P., Bani, M., Incontri, A., Squillace, N., et al. (2017). Brief Report: Peripheral Monocyte/Macrophage Phenotypes Associated with the Evolution of Cognitive Performance in HIV-Infected Patients. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 76(2), 219-224 [10.1097/QAI.0000000000001480].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Brief Report: Peripheral Monocyte/Macrophage Phenotypes Associated with the Evolution of Cognitive Performance in HIV-Infected Patients|
|Autori:||Fabbiani, M; Muscatello, A; Perseghin, P; Bani, M; Incontri, A; Squillace, N; Lapadula, G; Gori, A; Bandera, A|
BANI, MARCO [Membro del Collaboration Group]
|Data di pubblicazione:||2017|
|Rivista:||JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/QAI.0000000000001480|
|Appare nelle tipologie:||01 - Articolo su rivista|