Interferon-λ (IFN-λ) is a central regulator of mucosal immunity; however, its signaling specificity relative to that of type I interferons is poorly defined. IFN-λ can induce antiviral interferon-stimulated genes (ISGs) in epithelia, while the effect of IFN-λ in non-epithelial cells remains unclear. Here we report that neutrophils responded to IFN-λ. We found that in addition to inducing ISG transcription, IFN-λ (but not IFN-β) specifically activated a translation-independent signaling pathway that diminished the production of reactive oxygen species and degranulation in neutrophils. In mice, IFN-λ was elicited by enteric viruses and acted on neutrophils to decrease oxidative stress and intestinal damage. Thus, IFN-λ acted as a unique immunomodulatory agent by modifying transcriptional and non-translational neutrophil responses, which might permit a controlled development of the inflammatory process.
Broggi, A., Tan, Y., Granucci, F., & Zanoni, I. (2017). IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function. NATURE IMMUNOLOGY, 18(10), 1084-1093.
Citazione: | Broggi, A., Tan, Y., Granucci, F., & Zanoni, I. (2017). IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function. NATURE IMMUNOLOGY, 18(10), 1084-1093. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | Si |
Titolo: | IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function |
Autori: | Broggi, A; Tan, Y; Granucci, F; Zanoni, I |
Autori: | ZANONI, IVAN (Corresponding) |
Data di pubblicazione: | 2017 |
Lingua: | English |
Rivista: | NATURE IMMUNOLOGY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/ni.3821 |
Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
ni.3821.pdf | N/A | Administrator Richiedi una copia |