Mesenchymal stromal/stem cells (MSCs) represent suitable candidates for regenerative medicine purposes given their ability to differentiate in several cellular lineages, to migrate to site of injury, to secrete soluble factors crucial for cell survival and proliferation, as well as to modulate immune response. Although the exact mechanisms of action are still under investigation, several MSC- based clinical trials developed for various diseases, including organ injuries, systemic diseases, chronic inflammatory and autoimmune pathologies are ongoing. Recently, the possibility of using less immunogenic and more specific MSC by- products (i.e. microvesicles and exosomes) to overcome MSC transplantation criticisms and side effects is currently under consideration

Desiato, G., Losurdo, M., Elia, C., Saccomano, A., Coco, S. (2018). Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine. In Frontiers in Stem Cell and Regenerative Medicine Research (pp. 55-129). Atta-ur-Rahman and Shazia Anjum.

Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine

Desiato, G;Losurdo, M;Coco, S
2018

Abstract

Mesenchymal stromal/stem cells (MSCs) represent suitable candidates for regenerative medicine purposes given their ability to differentiate in several cellular lineages, to migrate to site of injury, to secrete soluble factors crucial for cell survival and proliferation, as well as to modulate immune response. Although the exact mechanisms of action are still under investigation, several MSC- based clinical trials developed for various diseases, including organ injuries, systemic diseases, chronic inflammatory and autoimmune pathologies are ongoing. Recently, the possibility of using less immunogenic and more specific MSC by- products (i.e. microvesicles and exosomes) to overcome MSC transplantation criticisms and side effects is currently under consideration
Capitolo o saggio
Mesenchymal Stem Cells (MSCs), Exosomes, Microvesicles, Extracellular vesicles (EVs), Paracrine effects, Regenerative medicine, Genetic engineering, Stem cell therapy, Cell-free therapy, Neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, Multiple sclerosis, Osteoarthritis, Osteogenesis Imperfecta, Acute Kidney Injury, Myocardial Infarction, Wound Healing, MSC Clinical Trials
English
Frontiers in Stem Cell and Regenerative Medicine Research
2018
978-1-68108-590-6
8
Atta-ur-Rahman and Shazia Anjum
55
129
Desiato, G., Losurdo, M., Elia, C., Saccomano, A., Coco, S. (2018). Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine. In Frontiers in Stem Cell and Regenerative Medicine Research (pp. 55-129). Atta-ur-Rahman and Shazia Anjum.
none
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/175820
Citazioni
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
Social impact