Mesenchymal stromal/stem cells (MSCs) represent suitable candidates for regenerative medicine purposes given their ability to differentiate in several cellular lineages, to migrate to site of injury, to secrete soluble factors crucial for cell survival and proliferation, as well as to modulate immune response. Although the exact mechanisms of action are still under investigation, several MSC- based clinical trials developed for various diseases, including organ injuries, systemic diseases, chronic inflammatory and autoimmune pathologies are ongoing. Recently, the possibility of using less immunogenic and more specific MSC by- products (i.e. microvesicles and exosomes) to overcome MSC transplantation criticisms and side effects is currently under consideration
Desiato, G., Losurdo, M., Elia, C., Saccomano, A., Coco, S. (2018). Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine. In Frontiers in Stem Cell and Regenerative Medicine Research (pp. 55-129). Atta-ur-Rahman and Shazia Anjum.
Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine
Desiato, G;Losurdo, M;Coco, S
2018
Abstract
Mesenchymal stromal/stem cells (MSCs) represent suitable candidates for regenerative medicine purposes given their ability to differentiate in several cellular lineages, to migrate to site of injury, to secrete soluble factors crucial for cell survival and proliferation, as well as to modulate immune response. Although the exact mechanisms of action are still under investigation, several MSC- based clinical trials developed for various diseases, including organ injuries, systemic diseases, chronic inflammatory and autoimmune pathologies are ongoing. Recently, the possibility of using less immunogenic and more specific MSC by- products (i.e. microvesicles and exosomes) to overcome MSC transplantation criticisms and side effects is currently under consideration
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