Obesity and in particular the excessive visceral fat distribution is accompanied by several alterations at hormonal, inflammatory and endothelial level. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and on the other side to increase the cardiovascular morbidity. In these chapter we will examine the main mechanisms of obesity and obesity-related hypertension and in particular the role of sympathetic nervous system, the alterations of the renal function and at the microvascular level. We will also depict the role of insulin resistance as factor stimulating and potentiating the other mechanisms. The second part will be focalized on the major target organ damage linked with obesity and obesity-related hypertension. We will finally describe the management and treatment of obesity and the antihypertensive drug therapies more effective in hypertensive obeses.

Seravalle, G., Grassi, G. (2017). Obesity and hypertension. PHARMACOLOGICAL RESEARCH, 122, 1-7 [10.1016/j.phrs.2017.05.013].

Obesity and hypertension

Seravalle, G;Grassi, G.
2017

Abstract

Obesity and in particular the excessive visceral fat distribution is accompanied by several alterations at hormonal, inflammatory and endothelial level. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and on the other side to increase the cardiovascular morbidity. In these chapter we will examine the main mechanisms of obesity and obesity-related hypertension and in particular the role of sympathetic nervous system, the alterations of the renal function and at the microvascular level. We will also depict the role of insulin resistance as factor stimulating and potentiating the other mechanisms. The second part will be focalized on the major target organ damage linked with obesity and obesity-related hypertension. We will finally describe the management and treatment of obesity and the antihypertensive drug therapies more effective in hypertensive obeses.
Articolo in rivista - Review Essay
Cardiovascular risk; Hypertension; Pathophysiological mechanisms; Target organ damage; Treatment; Visceral fat distribution;
English
2017
122
1
7
none
Seravalle, G., Grassi, G. (2017). Obesity and hypertension. PHARMACOLOGICAL RESEARCH, 122, 1-7 [10.1016/j.phrs.2017.05.013].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/175201
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