Background: The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Methods: Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. Results: In one case the overlap condition was associated with psoriatric arthritis, and the patient successfully underwent dual treatment with ursodeoxycholic acid and the anti-tumour necrosis factor-alpha agent adalimumab. In the second case, the predominant condition was, initially, an antimitochondrial antibody-negative primary biliary cirrhosis with progressive course towards end-stage liver disease; the patient then developed either antimitochondrial antibody positivity or changes in the biliary tree compatible with primary sclerosing cholangitis. Conclusions: These two cases add information on a controversial issue in the literature, and indicate the importance of recognizing a possible overlap syndrome to optimize treatment.

Floreani, A., Motta, R., Cazzagon, N., Franceschet, I., Roncalli, M., Del Ross, T., et al. (2015). The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. DIGESTIVE AND LIVER DISEASE, 47(5), 432-435 [10.1016/j.dld.2015.02.002].

The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis

Invernizzi, P.
2015

Abstract

Background: The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Methods: Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. Results: In one case the overlap condition was associated with psoriatric arthritis, and the patient successfully underwent dual treatment with ursodeoxycholic acid and the anti-tumour necrosis factor-alpha agent adalimumab. In the second case, the predominant condition was, initially, an antimitochondrial antibody-negative primary biliary cirrhosis with progressive course towards end-stage liver disease; the patient then developed either antimitochondrial antibody positivity or changes in the biliary tree compatible with primary sclerosing cholangitis. Conclusions: These two cases add information on a controversial issue in the literature, and indicate the importance of recognizing a possible overlap syndrome to optimize treatment.
Articolo in rivista - Articolo scientifico
Overlap syndrome; Primary biliary cirrhosis; Primary sclerosing cholangitis;
Overlap syndrome; Primary biliary cirrhosis; Primary sclerosing cholangitis; Arthritis, Psoriatic; Autoantibodies; Cholangitis, Sclerosing; Comorbidity; Female; Humans; Liver; Liver Cirrhosis, Biliary; Middle Aged; Mitochondria; Syndrome; Tumor Necrosis Factor-alpha; Ursodeoxycholic Acid; Hepatology; Gastroenterology
English
432
435
4
Floreani, A., Motta, R., Cazzagon, N., Franceschet, I., Roncalli, M., Del Ross, T., et al. (2015). The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. DIGESTIVE AND LIVER DISEASE, 47(5), 432-435 [10.1016/j.dld.2015.02.002].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/174345
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