Introduction: Primary biliary cholangitis (PBC) is an immune-mediated liver disease characterized by chronic inflammation of the intrahepatic bile ducts, causing progressive ductopenia, cholestasis and fibrosis, and leading to liver failure. Ursodeoxycholic acid (UDCA) is the first-line therapy for the treatment of PBC patients. This is effective in majority of patients; however, up to 20 percent of patients have an incomplete response to UDCA therapy and have a reduced prognosis as compared to healthy individuals. Obeticholic acid (OCA) has been recently registered as second-line therapy for patients with incomplete response to UDCA, with plans to demonstrate the long-term clinical efficacy. Areas covered: Recent evolution in our understanding of disease mechanisms is leading to the advent of new and re-purposed therapeutic agents targeting key processes in the etiopathogenesis. Several therapeutic targets have been proposed which can be categorized into three compartments: immune, biliary and fibrosis. In this review we describe the main biological mechanisms underpinning disease development and progression in PBC and the new targeted therapies on the horizon. Expert commentary: Testing new drugs towards hard clinical endpoints is challenging in PBC due to its low prevalence and the slow progression of the disease. Novel promising biomarkers are under study and should be evaluated as surrogate endpoints in clinical trials.

Ronca, V., Carbone, M., Bernuzzi, F., Malinverno, F., Mousa, H., Gershwin, M., et al. (2017). From pathogenesis to novel therapies in the treatment of primary biliary cholangitis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 13(12), 1121-1131 [10.1080/1744666X.2017.1391093].

From pathogenesis to novel therapies in the treatment of primary biliary cholangitis

Carbone, M;Bernuzzi, F;Malinverno, F;Invernizzi, P
2017

Abstract

Introduction: Primary biliary cholangitis (PBC) is an immune-mediated liver disease characterized by chronic inflammation of the intrahepatic bile ducts, causing progressive ductopenia, cholestasis and fibrosis, and leading to liver failure. Ursodeoxycholic acid (UDCA) is the first-line therapy for the treatment of PBC patients. This is effective in majority of patients; however, up to 20 percent of patients have an incomplete response to UDCA therapy and have a reduced prognosis as compared to healthy individuals. Obeticholic acid (OCA) has been recently registered as second-line therapy for patients with incomplete response to UDCA, with plans to demonstrate the long-term clinical efficacy. Areas covered: Recent evolution in our understanding of disease mechanisms is leading to the advent of new and re-purposed therapeutic agents targeting key processes in the etiopathogenesis. Several therapeutic targets have been proposed which can be categorized into three compartments: immune, biliary and fibrosis. In this review we describe the main biological mechanisms underpinning disease development and progression in PBC and the new targeted therapies on the horizon. Expert commentary: Testing new drugs towards hard clinical endpoints is challenging in PBC due to its low prevalence and the slow progression of the disease. Novel promising biomarkers are under study and should be evaluated as surrogate endpoints in clinical trials.
Articolo in rivista - Articolo scientifico
ASBT antagonists; FGF-19; OCA; Primary biliary cholangitis; TGR-5 agonist; Ustekinumab; autoimmune liver disease; fibrates; novel therapies; ursodeoxycholic acid
English
1121
1131
11
Ronca, V., Carbone, M., Bernuzzi, F., Malinverno, F., Mousa, H., Gershwin, M., et al. (2017). From pathogenesis to novel therapies in the treatment of primary biliary cholangitis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 13(12), 1121-1131 [10.1080/1744666X.2017.1391093].
Ronca, V; Carbone, M; Bernuzzi, F; Malinverno, F; Mousa, H; Gershwin, M; Invernizzi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/174255
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