In healthy subjects, progressive beat-to-beat increases or decreases in systolic blood pressure (SBP) ramps are not always accompanied by baroreflex-driven lengthening or shortening in pulse interval (PI) ramps, respectively. This phenomenon has been quantified by a new index, the baroreflex effectiveness index (BEI), defined as the ratio between the number of SBP ramps followed by the respective reflex PI ramps and the total number of SBP ramps observed in a given time window. Specificity of BEI was shown in eight cats by a -89% reduction of BEI after sinoaortic denervation. In 14 healthy humans, the 24-h average BEI value was 0.21, with a marked day-night modulation ( approximately 0.25 day, approximately 0.15 night) in counterphase with modulation of baroreflex sensitivity (BRS). Our analysis indicates that 1) in normal subjects, arterial baroreflex can induce beat-by-beat PI changes in response to only 21% of all SBP ramps, possibly because of central inhibitory influences or of interferences at sinus node level by nonbaroreflex mechanisms and 2) BEI provides information on the baroreflex function that is complementary to BRS

DI RIENZO, M., Parati, G., Castiglioni, P., Tordi, R., Mancia, G., Pedotti, A. (2001). Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life. AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 280(3), R744-R751.

Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life

DI RIENZO, MARCO
Primo
;
PARATI, GIANFRANCO
Secondo
;
MANCIA, GIUSEPPE
Penultimo
;
2001

Abstract

In healthy subjects, progressive beat-to-beat increases or decreases in systolic blood pressure (SBP) ramps are not always accompanied by baroreflex-driven lengthening or shortening in pulse interval (PI) ramps, respectively. This phenomenon has been quantified by a new index, the baroreflex effectiveness index (BEI), defined as the ratio between the number of SBP ramps followed by the respective reflex PI ramps and the total number of SBP ramps observed in a given time window. Specificity of BEI was shown in eight cats by a -89% reduction of BEI after sinoaortic denervation. In 14 healthy humans, the 24-h average BEI value was 0.21, with a marked day-night modulation ( approximately 0.25 day, approximately 0.15 night) in counterphase with modulation of baroreflex sensitivity (BRS). Our analysis indicates that 1) in normal subjects, arterial baroreflex can induce beat-by-beat PI changes in response to only 21% of all SBP ramps, possibly because of central inhibitory influences or of interferences at sinus node level by nonbaroreflex mechanisms and 2) BEI provides information on the baroreflex function that is complementary to BRS
Articolo in rivista - Articolo scientifico
Adult; Animals; Aorta, Thoracic; Baroreflex; Blood Pressure; Carotid Sinus; Cats; Denervation; Female; Humans; Kinetics; Male; Pulse; Sensitivity and Specificity; Heart Rate
English
2001
280
3
R744
R751
none
DI RIENZO, M., Parati, G., Castiglioni, P., Tordi, R., Mancia, G., Pedotti, A. (2001). Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life. AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 280(3), R744-R751.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/173785
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