IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishAntiphospholipid-mediated endothelium perturbation plays a role in antiphospholipid syndrome (APS)-associated vasculopathy. Antiphospholipid antibodies activate endothelium both in vitro and in vivo experimental models by inducing a pro-inflammatory/-coagulant phenotype; the antibodies recognize β2 glycoprotein I (β2GPI) on human endothelial cells (EC) from different parts of the vasculature. In spite of such large in vitro evidence, few studies have addressed the issue whether or not a comparable endothelial perturbation might be detectable in vivo. We investigated several indirect ex vivo parameters of endothelial dysfunction: plasma levels of soluble adhesion molecules (sADM), soluble thrombomodulin (sTM), von Willebrand factor (vWF) and tissue plasminogen activator (t-PA) by solid-phase assays. The study included: patients with primary antiphospholipid syndrome (n=32), with the syndrome secondary to non-active systemic lupus erythematosus (SLE, n=10), six patients with persistent antiphospholipid positivity at medium/high titre without any clinical manifestation of the syndrome. Fifty-two age and sex matched healthy subjects have been enrolled as controls. In addition, circulating endothelial cells identified by flow cytometry and the brachial artery flow-mediated vasodilation (FMV) were evaluated in 26 patients (20 primary and 6 lupus syndromes) and 30 healthy controls. Plasma levels of soluble adhesion molecules did not differ from controls, while a significant increase in von Willebrand factor titres (P<0.05) was found. No significant difference was found regarding the number of circulating endothelial cells and flow-mediated vasodilation. As a whole, these findings do suggest that antiphospholipid antibodies per se are not able to support a full-blown endothelial perturbation in vivo. As shown in antiphospholipid syndrome experimental animal models, a two-hit hypothesis is suggested. © 2004 Elsevier Ltd. All rights reserved
Meroni, P., Borghi, M., Raschi, E., Ventura, D., Sarzi Puttini, P., Atzeni, F., et al. (2004). Inflammatory response and the endothelium. THROMBOSIS RESEARCH, 114(5-6 SPEC. ISS.), 329-334.
| Citazione: | Meroni, P., Borghi, M., Raschi, E., Ventura, D., Sarzi Puttini, P., Atzeni, F., et al. (2004). Inflammatory response and the endothelium. THROMBOSIS RESEARCH, 114(5-6 SPEC. ISS.), 329-334. | |
| Tipo: | Articolo in rivista - Review Essay | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Inflammatory response and the endothelium | |
| Autori: | Meroni, P; Borghi, M; Raschi, E; Ventura, D; Sarzi Puttini, P; Atzeni, F; Lonati, L; Parati, G; Tincani, A; Mari, D; Tedesco, F | |
| Autori: | ||
| Data di pubblicazione: | 2004 | |
| Lingua: | English | |
| Rivista: | THROMBOSIS RESEARCH | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.thromres.2004.06.045 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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